The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron.
In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3527461?pdf=render |
| _version_ | 1811288883529252864 |
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| author | Michael D Forrest Mark J Wall Daniel A Press Jianfeng Feng |
| author_facet | Michael D Forrest Mark J Wall Daniel A Press Jianfeng Feng |
| author_sort | Michael D Forrest |
| collection | DOAJ |
| description | In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is selected. We have constructed a realistic biophysical Purkinje cell model that can replicate these patterns. In this model, Na(+)/K(+) pump activity sets the Purkinje cell's operating mode. From rat cerebellar slices we present Purkinje whole cell recordings in the presence of ouabain, which irreversibly blocks the Na(+)/K(+) pump. The model can replicate these recordings. We propose that Na(+)/K(+) pump activity controls the intrinsic firing mode of cerbellar Purkinje cells. |
| first_indexed | 2024-04-13T03:45:17Z |
| format | Article |
| id | doaj.art-f0072f5bc152491e94c3877a10b3825d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T03:45:17Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f0072f5bc152491e94c3877a10b3825d2022-12-22T03:04:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5116910.1371/journal.pone.0051169The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron.Michael D ForrestMark J WallDaniel A PressJianfeng FengIn vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is selected. We have constructed a realistic biophysical Purkinje cell model that can replicate these patterns. In this model, Na(+)/K(+) pump activity sets the Purkinje cell's operating mode. From rat cerebellar slices we present Purkinje whole cell recordings in the presence of ouabain, which irreversibly blocks the Na(+)/K(+) pump. The model can replicate these recordings. We propose that Na(+)/K(+) pump activity controls the intrinsic firing mode of cerbellar Purkinje cells.http://europepmc.org/articles/PMC3527461?pdf=render |
| spellingShingle | Michael D Forrest Mark J Wall Daniel A Press Jianfeng Feng The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. PLoS ONE |
| title | The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. |
| title_full | The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. |
| title_fullStr | The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. |
| title_full_unstemmed | The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. |
| title_short | The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. |
| title_sort | sodium potassium pump controls the intrinsic firing of the cerebellar purkinje neuron |
| url | http://europepmc.org/articles/PMC3527461?pdf=render |
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