A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A

A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A

Cytochrome P450 is an important enzyme that metabolizes a variety of chemicals, including exogenous substances, such as drugs and environmental chemicals, and endogenous substances, such as steroids, fatty acids, and cholesterol. Some CYPs show interspecific differences in terms of genetic variation...

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Bibliographic Details
Main Authors: Kanami Watanabe, Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Mayumi Ishizuka
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Animals
Subjects:
cytochrome P450
genome database
phylogenetics tree
Asian elephant
African elephant
Afrotheria
Online Access:https://www.mdpi.com/2076-2615/13/12/1939

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