Effects of Rivaroxaban on Coagulation Assays in Patients with Small Pulmonary Embolism and Deep Vein Thrombosis in Relation to Body Mass Index
<strong>Introduction:</strong> Rivaroxaban is a new anticoagulant medication for pulmonary thromboembolism (PTE) and deep vein thrombosis (DVT). There are limited data on the effect of body mass index (BMI) on the pharmacokinetics of rivaroxaban. This study aimed to assess the effect of...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-09-01
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| Series: | Journal of Cardio-Thoracic Medicine |
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| Online Access: | http://jctm.mums.ac.ir/article_13760_38035cc4a0d29f3e37e93dd31280fdbe.pdf |
| _version_ | 1818492424000897024 |
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| author | Shima Ghahremani Esmat Asaei Mahmoud Shabestari Majid Jalalyazdi |
| author_facet | Shima Ghahremani Esmat Asaei Mahmoud Shabestari Majid Jalalyazdi |
| author_sort | Shima Ghahremani |
| collection | DOAJ |
| description | <strong>Introduction:</strong> Rivaroxaban is a new anticoagulant medication for pulmonary thromboembolism (PTE) and deep vein thrombosis (DVT). There are limited data on the effect of body mass index (BMI) on the pharmacokinetics of rivaroxaban. This study aimed to assess the effect of rivaroxaban on coagulation assays in relation to BMI in PTE and DVT patients.<br /> <strong>Materials and Methods</strong><strong>: </strong>the present cohort studywas conducted on patients with DVT and PTE who were planned to receive rivaroxaban (15 mg bid). Demographic characteristics, as well as anthropometric measurements, were recorded before the rivaroxaban administration. Prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR) were measured before and after 4-6 days of treatment with rivaroxaban. The data were analyzed using paired t-test and analysis of covariance in SPSS software, version 20 (IBM Inc., Chicago, Il, USA)<br /> <strong>Results: </strong>This study was carried out on 100subjects (i.e., 45 males and 55 females) with the mean age of 38.8±1.7 years. The majority of the subjects (68%) had normal creatinine clearance. The results of the research revealed a significant increase in PT, PT, and INR after the administration of rivaroxaban in both normal-weight and obese subjects (P40 years), gender, and creatinine clearance (i.e., normal and abnormal) groups (P <strong>Conclusion: </strong>The findings of this study indicated a significant increase in coagulation assays in both normal weight and obese subjects; however, the final PT increment was reduced by BMI. |
| first_indexed | 2024-12-10T17:43:10Z |
| format | Article |
| id | doaj.art-f008678ed4af45e2bb064a23b741f8cd |
| institution | Directory Open Access Journal |
| issn | 2345-2447 2322-5750 |
| language | English |
| last_indexed | 2024-12-10T17:43:10Z |
| publishDate | 2019-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardio-Thoracic Medicine |
| spelling | doaj.art-f008678ed4af45e2bb064a23b741f8cd2022-12-22T01:39:20ZengMashhad University of Medical SciencesJournal of Cardio-Thoracic Medicine2345-24472322-57502019-09-017349149810.22038/jctm.2019.41968.123913760Effects of Rivaroxaban on Coagulation Assays in Patients with Small Pulmonary Embolism and Deep Vein Thrombosis in Relation to Body Mass IndexShima Ghahremani0Esmat Asaei1Mahmoud Shabestari2Majid Jalalyazdi3MD, Faculty of Medicine, Mashhad Medical Sciences Branch,Islamic Azad University, Mashhad, IranCardiologist, Department of cardiology, Mashhad Medical Sciences Branch,Islamic Azad University, Mashhad, IranCardiologist, Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCardiologist, Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran<strong>Introduction:</strong> Rivaroxaban is a new anticoagulant medication for pulmonary thromboembolism (PTE) and deep vein thrombosis (DVT). There are limited data on the effect of body mass index (BMI) on the pharmacokinetics of rivaroxaban. This study aimed to assess the effect of rivaroxaban on coagulation assays in relation to BMI in PTE and DVT patients.<br /> <strong>Materials and Methods</strong><strong>: </strong>the present cohort studywas conducted on patients with DVT and PTE who were planned to receive rivaroxaban (15 mg bid). Demographic characteristics, as well as anthropometric measurements, were recorded before the rivaroxaban administration. Prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR) were measured before and after 4-6 days of treatment with rivaroxaban. The data were analyzed using paired t-test and analysis of covariance in SPSS software, version 20 (IBM Inc., Chicago, Il, USA)<br /> <strong>Results: </strong>This study was carried out on 100subjects (i.e., 45 males and 55 females) with the mean age of 38.8±1.7 years. The majority of the subjects (68%) had normal creatinine clearance. The results of the research revealed a significant increase in PT, PT, and INR after the administration of rivaroxaban in both normal-weight and obese subjects (P40 years), gender, and creatinine clearance (i.e., normal and abnormal) groups (P <strong>Conclusion: </strong>The findings of this study indicated a significant increase in coagulation assays in both normal weight and obese subjects; however, the final PT increment was reduced by BMI.http://jctm.mums.ac.ir/article_13760_38035cc4a0d29f3e37e93dd31280fdbe.pdfBlood coagulant assaysRivaroxabanDeep Vein ThrombosisPulmonary Thromboembolism |
| spellingShingle | Shima Ghahremani Esmat Asaei Mahmoud Shabestari Majid Jalalyazdi Effects of Rivaroxaban on Coagulation Assays in Patients with Small Pulmonary Embolism and Deep Vein Thrombosis in Relation to Body Mass Index Journal of Cardio-Thoracic Medicine Blood coagulant assays Rivaroxaban Deep Vein Thrombosis Pulmonary Thromboembolism |
| title | Effects of Rivaroxaban on Coagulation Assays in Patients with Small Pulmonary Embolism and Deep Vein Thrombosis in Relation to Body Mass Index |
| title_full | Effects of Rivaroxaban on Coagulation Assays in Patients with Small Pulmonary Embolism and Deep Vein Thrombosis in Relation to Body Mass Index |
| title_fullStr | Effects of Rivaroxaban on Coagulation Assays in Patients with Small Pulmonary Embolism and Deep Vein Thrombosis in Relation to Body Mass Index |
| title_full_unstemmed | Effects of Rivaroxaban on Coagulation Assays in Patients with Small Pulmonary Embolism and Deep Vein Thrombosis in Relation to Body Mass Index |
| title_short | Effects of Rivaroxaban on Coagulation Assays in Patients with Small Pulmonary Embolism and Deep Vein Thrombosis in Relation to Body Mass Index |
| title_sort | effects of rivaroxaban on coagulation assays in patients with small pulmonary embolism and deep vein thrombosis in relation to body mass index |
| topic | Blood coagulant assays Rivaroxaban Deep Vein Thrombosis Pulmonary Thromboembolism |
| url | http://jctm.mums.ac.ir/article_13760_38035cc4a0d29f3e37e93dd31280fdbe.pdf |
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