Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding
High-fat diet habits lead to an increase in LDL-C levels that eventually influence the atherosclerotic plaque formation and progression, causing coronary heart disease. Atherosclerosis is a chronic inflammatory process that releases various pro-inflammatory cytokines, including IL-6. Indonesians oft...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2023-06-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2961 |
| _version_ | 1797263161487785984 |
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| author | Penny Setyawati Martioso Diana Krisanti Jasaputra Julia Windi Gunadi Ronny Lesmana Pinkan Al Shabrina |
| author_facet | Penny Setyawati Martioso Diana Krisanti Jasaputra Julia Windi Gunadi Ronny Lesmana Pinkan Al Shabrina |
| author_sort | Penny Setyawati Martioso |
| collection | DOAJ |
| description | High-fat diet habits lead to an increase in LDL-C levels that eventually influence the atherosclerotic plaque formation and progression, causing coronary heart disease. Atherosclerosis is a chronic inflammatory process that releases various pro-inflammatory cytokines, including IL-6. Indonesians often use medicinal plants to decrease cholesterol levels. This study aimed to compare the LDL-C and IL-6 levels after treatments of ethanol extracts from Java ginger (EEJG), turmeric (EET), garlic (EEG), and pomegranate flowers (EEPF) in a hypercholesterolemia animal model. This study was conducted at the Maranatha Biomedical Research Laboratory from June–December 2020. Male Wistar rats were divided into six groups (n=5 per group) and received high-fat feeding and 0.01% propylthiouracil. The following treatments were given for 28 days: oral carboxymethylcellulose 1% for negative control; 35 mg/200g of oral EEJG, EET, EEG, EEPF for respective treatment groups (n=5 groups); and 0.36 mg/200 g of oral Rosuvastatin for positive control. It was demonstrated that the mean LDL-C levels were 65.75 mg/dL, 55.25 mg/dL, 56.75 mg/dL, and 59.60 mg/dL for EEJG, EET, EEG, EEPF groups, respectively, which were significantly different from that of the negative control (81.73 mg/dL). The IL-6 levels of the EEJG (27.55 pg./mL) and EEG (27.54 pg./mL) group were significantly different from the EEPF group (24.5 pg./mL) but not significantly different from the negative control (25.58 pg./mL), EET (25.60 pg./mL), and rosuvastatin (26.09 pg./mL) groups. The administration of ethanol extracts of Java ginger, turmeric, garlic, and pomegranate flower decreases the C-LDL levels; however, only the ethanol extract of pomegranate flowers administered for 28 days decreases the IL-6 levels of Wistar rat hypercholesterolemia model, albeit insignificantly. |
| first_indexed | 2024-04-25T00:08:36Z |
| format | Article |
| id | doaj.art-f009f14d6d0d43348e74689a619118ef |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-04-25T00:08:36Z |
| publishDate | 2023-06-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-f009f14d6d0d43348e74689a619118ef2024-03-14T03:39:29ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232023-06-015521570Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat FeedingPenny Setyawati Martioso0Diana Krisanti Jasaputra1Julia Windi Gunadi2Ronny Lesmana3Pinkan Al Shabrina4Department of Clinical Pathology, Faculty of Medicine, Maranatha Christian University, BandungDepartment of Pharmacology, Faculty of Medicine, Maranatha Christian University, BandungDepartment of Physiology, Faculty of Medicine, Maranatha Christian University, BandungPhysiology Division, Department of Biomedical Sciences, Faculty of Medicine Universitas PadjadjaranFaculty of Medicine, Maranatha Christian University, BandungHigh-fat diet habits lead to an increase in LDL-C levels that eventually influence the atherosclerotic plaque formation and progression, causing coronary heart disease. Atherosclerosis is a chronic inflammatory process that releases various pro-inflammatory cytokines, including IL-6. Indonesians often use medicinal plants to decrease cholesterol levels. This study aimed to compare the LDL-C and IL-6 levels after treatments of ethanol extracts from Java ginger (EEJG), turmeric (EET), garlic (EEG), and pomegranate flowers (EEPF) in a hypercholesterolemia animal model. This study was conducted at the Maranatha Biomedical Research Laboratory from June–December 2020. Male Wistar rats were divided into six groups (n=5 per group) and received high-fat feeding and 0.01% propylthiouracil. The following treatments were given for 28 days: oral carboxymethylcellulose 1% for negative control; 35 mg/200g of oral EEJG, EET, EEG, EEPF for respective treatment groups (n=5 groups); and 0.36 mg/200 g of oral Rosuvastatin for positive control. It was demonstrated that the mean LDL-C levels were 65.75 mg/dL, 55.25 mg/dL, 56.75 mg/dL, and 59.60 mg/dL for EEJG, EET, EEG, EEPF groups, respectively, which were significantly different from that of the negative control (81.73 mg/dL). The IL-6 levels of the EEJG (27.55 pg./mL) and EEG (27.54 pg./mL) group were significantly different from the EEPF group (24.5 pg./mL) but not significantly different from the negative control (25.58 pg./mL), EET (25.60 pg./mL), and rosuvastatin (26.09 pg./mL) groups. The administration of ethanol extracts of Java ginger, turmeric, garlic, and pomegranate flower decreases the C-LDL levels; however, only the ethanol extract of pomegranate flowers administered for 28 days decreases the IL-6 levels of Wistar rat hypercholesterolemia model, albeit insignificantly.https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2961garlic, java ginger, high-fat feeding, il-6, pomegranate flowers, turmeric |
| spellingShingle | Penny Setyawati Martioso Diana Krisanti Jasaputra Julia Windi Gunadi Ronny Lesmana Pinkan Al Shabrina Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding Majalah Kedokteran Bandung garlic, java ginger, high-fat feeding, il-6, pomegranate flowers, turmeric |
| title | Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding |
| title_full | Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding |
| title_fullStr | Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding |
| title_full_unstemmed | Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding |
| title_short | Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding |
| title_sort | comparison of several indonesian medicinal plants effects on ldl c and il 6 levels in wistar rats after high fat feeding |
| topic | garlic, java ginger, high-fat feeding, il-6, pomegranate flowers, turmeric |
| url | https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2961 |
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