The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats
The objective of this study was to investigate the vasoregulatory role of perivascular adipose tissue (PVAT) and its mutual interaction with endogenous and exogenous H<sub>2</sub>S in the thoracic aorta (TA) of adult normotensive Wistar rats and spontaneously hypertensive rats (SHRs). In...
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MDPI AG
2022-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/3/457 |
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| author | Samuel Golas Andrea Berenyiova Miroslava Majzunova Magdalena Drobna Muobarak J. Tuorkey Sona Cacanyiova |
| author_facet | Samuel Golas Andrea Berenyiova Miroslava Majzunova Magdalena Drobna Muobarak J. Tuorkey Sona Cacanyiova |
| author_sort | Samuel Golas |
| collection | DOAJ |
| description | The objective of this study was to investigate the vasoregulatory role of perivascular adipose tissue (PVAT) and its mutual interaction with endogenous and exogenous H<sub>2</sub>S in the thoracic aorta (TA) of adult normotensive Wistar rats and spontaneously hypertensive rats (SHRs). In SHRs, hypertension was associated with cardiac hypertrophy and increased contractility. Regardless of the strain, PVAT revealed an anticontractile effect; however, PVAT worsened endothelial-dependent vasorelaxation. Since H<sub>2</sub>S produced by both the vascular wall and PVAT had a pro-contractile effect in SHRs, H<sub>2</sub>S decreased the sensitivity of adrenergic receptors to noradrenaline in Wistar rats. While H<sub>2</sub>S had no contribution to endothelium-dependent relaxation in Wistar rats, in SHRs, H<sub>2</sub>S produced by the vascular wall had a pro-relaxant effect. We observed a larger vasorelaxation induced by exogenous H<sub>2</sub>S donor in SHRs than in Wistar rats. Additionally, in the presence of PVAT, this effect was potentiated. We demonstrated that PVAT of the TA aggravated endothelial function in SHRs. However, H<sub>2</sub>S produced by the TA vascular wall had a pro-relaxation effect, and PVAT revealed anti-contractile activity mediated by the release of an unknown factor and potentiated the vasorelaxation induced by exogenous H<sub>2</sub>S. All these actions could represent a form of compensatory mechanism to balance impaired vascular tone regulation. |
| first_indexed | 2024-03-09T13:49:36Z |
| format | Article |
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| language | English |
| last_indexed | 2024-03-09T13:49:36Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-f00a5bd3b849432099af3671b23b36032023-11-30T20:53:10ZengMDPI AGBiomolecules2218-273X2022-03-0112345710.3390/biom12030457The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive RatsSamuel Golas0Andrea Berenyiova1Miroslava Majzunova2Magdalena Drobna3Muobarak J. Tuorkey4Sona Cacanyiova5Center of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, SlovakiaCenter of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, SlovakiaCenter of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, SlovakiaCenter of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, SlovakiaZoology Department, Division of Physiology, Faculty of Science, Damanhour University, Damanhour 22514, EgyptCenter of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, SlovakiaThe objective of this study was to investigate the vasoregulatory role of perivascular adipose tissue (PVAT) and its mutual interaction with endogenous and exogenous H<sub>2</sub>S in the thoracic aorta (TA) of adult normotensive Wistar rats and spontaneously hypertensive rats (SHRs). In SHRs, hypertension was associated with cardiac hypertrophy and increased contractility. Regardless of the strain, PVAT revealed an anticontractile effect; however, PVAT worsened endothelial-dependent vasorelaxation. Since H<sub>2</sub>S produced by both the vascular wall and PVAT had a pro-contractile effect in SHRs, H<sub>2</sub>S decreased the sensitivity of adrenergic receptors to noradrenaline in Wistar rats. While H<sub>2</sub>S had no contribution to endothelium-dependent relaxation in Wistar rats, in SHRs, H<sub>2</sub>S produced by the vascular wall had a pro-relaxant effect. We observed a larger vasorelaxation induced by exogenous H<sub>2</sub>S donor in SHRs than in Wistar rats. Additionally, in the presence of PVAT, this effect was potentiated. We demonstrated that PVAT of the TA aggravated endothelial function in SHRs. However, H<sub>2</sub>S produced by the TA vascular wall had a pro-relaxation effect, and PVAT revealed anti-contractile activity mediated by the release of an unknown factor and potentiated the vasorelaxation induced by exogenous H<sub>2</sub>S. All these actions could represent a form of compensatory mechanism to balance impaired vascular tone regulation.https://www.mdpi.com/2218-273X/12/3/457adipose tissueH<sub>2</sub>Sthoracic aortaWistarSHRessential hypertension |
| spellingShingle | Samuel Golas Andrea Berenyiova Miroslava Majzunova Magdalena Drobna Muobarak J. Tuorkey Sona Cacanyiova The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats Biomolecules adipose tissue H<sub>2</sub>S thoracic aorta Wistar SHR essential hypertension |
| title | The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats |
| title_full | The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats |
| title_fullStr | The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats |
| title_full_unstemmed | The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats |
| title_short | The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats |
| title_sort | vasoactive effect of perivascular adipose tissue and hydrogen sulfide in thoracic aortas of normotensive and spontaneously hypertensive rats |
| topic | adipose tissue H<sub>2</sub>S thoracic aorta Wistar SHR essential hypertension |
| url | https://www.mdpi.com/2218-273X/12/3/457 |
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