<b>Synthesis of substituted flavone derivatives as potent antimicrobial agents</b>
The biological activity of flavone has been enhanced by introducing heteroaryl moiety in C-2 position of chromone derivatives. Thus, 2-(1<i>H</i>-Indol-3-yl)-4<i>H</i>-chromen-4-one derivatives (<b>6a</b>-<b>e</b>) and 2-(2-chloroquinolin-3-yl)-4<i&...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Chemical Society of Ethiopia
2011-12-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://ajol.info/index.php/bcse/article/view/68594 |
| Summary: | The biological activity of flavone has been enhanced by introducing heteroaryl moiety in C-2 position of chromone derivatives. Thus, 2-(1<i>H</i>-Indol-3-yl)-4<i>H</i>-chromen-4-one derivatives (<b>6a</b>-<b>e</b>) and 2-(2-chloroquinolin-3-yl)-4<i>H</i>-chromen-4-one derivatives (<b>7a</b>-<b>e</b>) were synthesized from corresponding chalcone. They were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. |
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| ISSN: | 1011-3924 1726-801X |