Nerve trunk healing and neuroma formation after nerve transection injury
The nerve trunk healing process of a transected peripheral nerve trunk is composed of angiogenesis, nerve fiber regeneration, and scarring. Nerve trunk healing and neuroma formation probably share identical molecular mediators and similar regulations. At the nerve transection site, angiogenesis is s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1184246/full |
| _version_ | 1797806337526071296 |
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| author | Dong-Xu Huang Ming-Xi Yang Zhen-Min Jiang Miao Chen Kun Chang Yong-Xin Zhan Xu Gong |
| author_facet | Dong-Xu Huang Ming-Xi Yang Zhen-Min Jiang Miao Chen Kun Chang Yong-Xin Zhan Xu Gong |
| author_sort | Dong-Xu Huang |
| collection | DOAJ |
| description | The nerve trunk healing process of a transected peripheral nerve trunk is composed of angiogenesis, nerve fiber regeneration, and scarring. Nerve trunk healing and neuroma formation probably share identical molecular mediators and similar regulations. At the nerve transection site, angiogenesis is sufficient and necessary for nerve fiber regeneration. Angiogenesis and nerve fiber regeneration reveal a positive correlation in the early time. Scarring and nerve fiber regeneration show a negative correlation in the late phase. We hypothesize that anti-angiogenesis suppresses neuromas. Subsequently, we provide potential protocols to test our hypothesis. Finally, we recommend employing anti-angiogenic small-molecule protein kinase inhibitors to investigate nerve transection injuries. |
| first_indexed | 2024-03-13T06:05:50Z |
| format | Article |
| id | doaj.art-f00bc2ee2c65480db5fc981c0f8d8c20 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T06:05:50Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f00bc2ee2c65480db5fc981c0f8d8c202023-06-12T04:31:52ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-06-011410.3389/fneur.2023.11842461184246Nerve trunk healing and neuroma formation after nerve transection injuryDong-Xu HuangMing-Xi YangZhen-Min JiangMiao ChenKun ChangYong-Xin ZhanXu GongThe nerve trunk healing process of a transected peripheral nerve trunk is composed of angiogenesis, nerve fiber regeneration, and scarring. Nerve trunk healing and neuroma formation probably share identical molecular mediators and similar regulations. At the nerve transection site, angiogenesis is sufficient and necessary for nerve fiber regeneration. Angiogenesis and nerve fiber regeneration reveal a positive correlation in the early time. Scarring and nerve fiber regeneration show a negative correlation in the late phase. We hypothesize that anti-angiogenesis suppresses neuromas. Subsequently, we provide potential protocols to test our hypothesis. Finally, we recommend employing anti-angiogenic small-molecule protein kinase inhibitors to investigate nerve transection injuries.https://www.frontiersin.org/articles/10.3389/fneur.2023.1184246/fullperipheral nerve injuryangiogenesisnerve fiber regenerationscarringtraumatic neuromaprotein kinase inhibitor |
| spellingShingle | Dong-Xu Huang Ming-Xi Yang Zhen-Min Jiang Miao Chen Kun Chang Yong-Xin Zhan Xu Gong Nerve trunk healing and neuroma formation after nerve transection injury Frontiers in Neurology peripheral nerve injury angiogenesis nerve fiber regeneration scarring traumatic neuroma protein kinase inhibitor |
| title | Nerve trunk healing and neuroma formation after nerve transection injury |
| title_full | Nerve trunk healing and neuroma formation after nerve transection injury |
| title_fullStr | Nerve trunk healing and neuroma formation after nerve transection injury |
| title_full_unstemmed | Nerve trunk healing and neuroma formation after nerve transection injury |
| title_short | Nerve trunk healing and neuroma formation after nerve transection injury |
| title_sort | nerve trunk healing and neuroma formation after nerve transection injury |
| topic | peripheral nerve injury angiogenesis nerve fiber regeneration scarring traumatic neuroma protein kinase inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1184246/full |
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