Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity
Background: Hemorrhagic transformation (HT) is a severe complication in patients with acute ischemic stroke (AIS). This study was performed to explore and validate the relation between bilirubin levels and spontaneous HT (sHT) and HT after mechanical thrombectomy (tHT). Methods: The study population...
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1471 |
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| author | Jiahao Chen Yiting Chen Yisi Lin Jingfang Long Yufeng Chen Jincai He Guiqian Huang |
| author_facet | Jiahao Chen Yiting Chen Yisi Lin Jingfang Long Yufeng Chen Jincai He Guiqian Huang |
| author_sort | Jiahao Chen |
| collection | DOAJ |
| description | Background: Hemorrhagic transformation (HT) is a severe complication in patients with acute ischemic stroke (AIS). This study was performed to explore and validate the relation between bilirubin levels and spontaneous HT (sHT) and HT after mechanical thrombectomy (tHT). Methods: The study population consisted of 408 consecutive AIS patients with HT and age- and sex-matched patients without HT. All patients were divided into quartiles according to total bilirubin (TBIL) level. HT was classified as hemorrhagic infarction (HI) and parenchymal hematoma (PH) based on radiographic data. Results: In this study, the baseline TBIL levels were significantly higher in the HT than non-HT patients in both cohorts (<i>p</i> < 0.001). Furthermore, the severity of HT increased with increasing TBIL levels (<i>p</i> < 0.001) in sHT and tHT cohorts. The highest quartile of TBIL was associated with HT in sHT and tHT cohorts (sHT cohort: OR = 3.924 (2.051–7.505), <i>p</i> < 0.001; tHT cohort: OR = 3.557 (1.662–7.611), <i>p</i> = 0.006). Conclusions: Our results suggest that an increased TBIL is associated with a high risk of patients with sHT and tHT, and that TBIL is more suitable as a predictor for sHT than tHT. These findings may help to identify patients susceptible to different types and severity of HT. |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:13Z |
| publishDate | 2023-02-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-f00c4286386d47d7a3a9726e7f08a2ee2023-11-16T21:20:03ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124147110.3390/jcm12041471Roles of Bilirubin in Hemorrhagic Transformation of Different Types and SeverityJiahao Chen0Yiting Chen1Yisi Lin2Jingfang Long3Yufeng Chen4Jincai He5Guiqian Huang6Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaSchool of Foreign Language Studies, Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of General Practice, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaBackground: Hemorrhagic transformation (HT) is a severe complication in patients with acute ischemic stroke (AIS). This study was performed to explore and validate the relation between bilirubin levels and spontaneous HT (sHT) and HT after mechanical thrombectomy (tHT). Methods: The study population consisted of 408 consecutive AIS patients with HT and age- and sex-matched patients without HT. All patients were divided into quartiles according to total bilirubin (TBIL) level. HT was classified as hemorrhagic infarction (HI) and parenchymal hematoma (PH) based on radiographic data. Results: In this study, the baseline TBIL levels were significantly higher in the HT than non-HT patients in both cohorts (<i>p</i> < 0.001). Furthermore, the severity of HT increased with increasing TBIL levels (<i>p</i> < 0.001) in sHT and tHT cohorts. The highest quartile of TBIL was associated with HT in sHT and tHT cohorts (sHT cohort: OR = 3.924 (2.051–7.505), <i>p</i> < 0.001; tHT cohort: OR = 3.557 (1.662–7.611), <i>p</i> = 0.006). Conclusions: Our results suggest that an increased TBIL is associated with a high risk of patients with sHT and tHT, and that TBIL is more suitable as a predictor for sHT than tHT. These findings may help to identify patients susceptible to different types and severity of HT.https://www.mdpi.com/2077-0383/12/4/1471acute ischemic strokehemorrhagic transformationbilirubinmechanical thrombectomypredictor |
| spellingShingle | Jiahao Chen Yiting Chen Yisi Lin Jingfang Long Yufeng Chen Jincai He Guiqian Huang Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity Journal of Clinical Medicine acute ischemic stroke hemorrhagic transformation bilirubin mechanical thrombectomy predictor |
| title | Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity |
| title_full | Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity |
| title_fullStr | Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity |
| title_full_unstemmed | Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity |
| title_short | Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity |
| title_sort | roles of bilirubin in hemorrhagic transformation of different types and severity |
| topic | acute ischemic stroke hemorrhagic transformation bilirubin mechanical thrombectomy predictor |
| url | https://www.mdpi.com/2077-0383/12/4/1471 |
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