Breast neuroendocrine tumor arising in the axilla of a man: a case report
Abstract Background Accessory breast carcinomas of the axilla of males are rare, and primary breast neuroendocrine tumors (BNETs) are rare as well. We present a case of a BNET arising in the axilla of a man. Case presentation A 64-year-old Japanese man presented with a hard 15-mm mass in the axilla...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-022-03683-2 |
| _version_ | 1811198356364460032 |
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| author | Kosei Kimura Shigeru Kawabata Hiroyo Oku Ayana Ikari Tomo Tominaga Saki Takai Junna Sakane Michiaki Tanaka Chinatsu Aoki Monika Ota Erika Minami Yoshinobu Hirose Sang-Woong Lee Mitsuhiko Iwamoto |
| author_facet | Kosei Kimura Shigeru Kawabata Hiroyo Oku Ayana Ikari Tomo Tominaga Saki Takai Junna Sakane Michiaki Tanaka Chinatsu Aoki Monika Ota Erika Minami Yoshinobu Hirose Sang-Woong Lee Mitsuhiko Iwamoto |
| author_sort | Kosei Kimura |
| collection | DOAJ |
| description | Abstract Background Accessory breast carcinomas of the axilla of males are rare, and primary breast neuroendocrine tumors (BNETs) are rare as well. We present a case of a BNET arising in the axilla of a man. Case presentation A 64-year-old Japanese man presented with a hard 15-mm mass in the axilla and axillary lymph node swelling. Histopathological examination of the incisional biopsy specimen revealed a neuroendocrine carcinoma. Therefore, wide radical excision of the axillary tumor and axillary lymph node dissection were performed. Hematoxylin and eosin staining showed that the solid tumor was mainly located in the subcutaneous adipose tissues and appeared to invade the skin. The tumor phenotypes were positive for CAM 5.2, synaptophysin, estrogen receptor, progesterone receptor, and GATA-binding protein 3; they were negative for human epidermal growth receptor 2. The neuroendocrine component comprised more than 90% of the tumor, and the Ki-67 index was 21%. These results indicated that the tumor was a BNET. This patient underwent adjuvant chemotherapy, endocrine therapy, and radiotherapy. Conclusions BNET cases in males are rare. The clinical and histological criteria as well as treatment for these rare cases are discussed. |
| first_indexed | 2024-04-12T01:30:12Z |
| format | Article |
| id | doaj.art-f00ca4e8ae79496187112d0091c15723 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-12T01:30:12Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-f00ca4e8ae79496187112d0091c157232022-12-22T03:53:31ZengBMCJournal of Medical Case Reports1752-19472022-12-011611510.1186/s13256-022-03683-2Breast neuroendocrine tumor arising in the axilla of a man: a case reportKosei Kimura0Shigeru Kawabata1Hiroyo Oku2Ayana Ikari3Tomo Tominaga4Saki Takai5Junna Sakane6Michiaki Tanaka7Chinatsu Aoki8Monika Ota9Erika Minami10Yoshinobu Hirose11Sang-Woong Lee12Mitsuhiko Iwamoto13Department of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Pathology, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Pathology, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityDepartment of Breast and Endocrine Surgery, Osaka Medical and Pharmaceutical UniversityAbstract Background Accessory breast carcinomas of the axilla of males are rare, and primary breast neuroendocrine tumors (BNETs) are rare as well. We present a case of a BNET arising in the axilla of a man. Case presentation A 64-year-old Japanese man presented with a hard 15-mm mass in the axilla and axillary lymph node swelling. Histopathological examination of the incisional biopsy specimen revealed a neuroendocrine carcinoma. Therefore, wide radical excision of the axillary tumor and axillary lymph node dissection were performed. Hematoxylin and eosin staining showed that the solid tumor was mainly located in the subcutaneous adipose tissues and appeared to invade the skin. The tumor phenotypes were positive for CAM 5.2, synaptophysin, estrogen receptor, progesterone receptor, and GATA-binding protein 3; they were negative for human epidermal growth receptor 2. The neuroendocrine component comprised more than 90% of the tumor, and the Ki-67 index was 21%. These results indicated that the tumor was a BNET. This patient underwent adjuvant chemotherapy, endocrine therapy, and radiotherapy. Conclusions BNET cases in males are rare. The clinical and histological criteria as well as treatment for these rare cases are discussed.https://doi.org/10.1186/s13256-022-03683-2Accessory breast carcinomaNeuroendocrine tumorMale breast cancerAxillary tumor |
| spellingShingle | Kosei Kimura Shigeru Kawabata Hiroyo Oku Ayana Ikari Tomo Tominaga Saki Takai Junna Sakane Michiaki Tanaka Chinatsu Aoki Monika Ota Erika Minami Yoshinobu Hirose Sang-Woong Lee Mitsuhiko Iwamoto Breast neuroendocrine tumor arising in the axilla of a man: a case report Journal of Medical Case Reports Accessory breast carcinoma Neuroendocrine tumor Male breast cancer Axillary tumor |
| title | Breast neuroendocrine tumor arising in the axilla of a man: a case report |
| title_full | Breast neuroendocrine tumor arising in the axilla of a man: a case report |
| title_fullStr | Breast neuroendocrine tumor arising in the axilla of a man: a case report |
| title_full_unstemmed | Breast neuroendocrine tumor arising in the axilla of a man: a case report |
| title_short | Breast neuroendocrine tumor arising in the axilla of a man: a case report |
| title_sort | breast neuroendocrine tumor arising in the axilla of a man a case report |
| topic | Accessory breast carcinoma Neuroendocrine tumor Male breast cancer Axillary tumor |
| url | https://doi.org/10.1186/s13256-022-03683-2 |
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