Exploring the potential of microfluidics for next-generation drug delivery systems
The platform of microfluidics offers a precise control and manipulation over fluids at a small scale and therefore has gained much attention in recent times. This topic is currently applied to automation and high-throughput analysis in several areas, including extraction of DNA, RNA and proteins, ge...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | OpenNano |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352952023000294 |
| _version_ | 1797803896408637440 |
|---|---|
| author | Gargi Bhattacharjee Nisarg Gohil Malvika Shukla Swati Sharma Indra Mani Alok Pandya Dinh-Toi Chu Nhat Le Bui Yen-Vy Nguyen Thi Khushal Khambhati Rupesh Maurya Suresh Ramakrishna Vijai Singh |
| author_facet | Gargi Bhattacharjee Nisarg Gohil Malvika Shukla Swati Sharma Indra Mani Alok Pandya Dinh-Toi Chu Nhat Le Bui Yen-Vy Nguyen Thi Khushal Khambhati Rupesh Maurya Suresh Ramakrishna Vijai Singh |
| author_sort | Gargi Bhattacharjee |
| collection | DOAJ |
| description | The platform of microfluidics offers a precise control and manipulation over fluids at a small scale and therefore has gained much attention in recent times. This topic is currently applied to automation and high-throughput analysis in several areas, including extraction of DNA, RNA and proteins, gene identification, gene assembly, cloning, single-cell analysis, organs grown on chips, PCR, drug screening, toxicity testing and drug delivery. Conventional methods used for drug delivery are sometimes non-targeted leading to loss of administered drugs and reduced drug effectiveness. Recent advances in microfluidics allow precise dose-dependent delivery of a drug to a targeted location. Several microfluidics designs have been implemented to improve the precision of treatment in clinics. This review highlights currently available tools in microfluidics, designs for drug carriers, delivery methods, robotics and artificial intelligence in the field of microfluidics. |
| first_indexed | 2024-03-13T05:28:56Z |
| format | Article |
| id | doaj.art-f00cb04d1a1b4a92b312504fa4d0fc89 |
| institution | Directory Open Access Journal |
| issn | 2352-9520 |
| language | English |
| last_indexed | 2024-03-13T05:28:56Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | OpenNano |
| spelling | doaj.art-f00cb04d1a1b4a92b312504fa4d0fc892023-06-15T04:56:32ZengElsevierOpenNano2352-95202023-07-0112100150Exploring the potential of microfluidics for next-generation drug delivery systemsGargi Bhattacharjee0Nisarg Gohil1Malvika Shukla2Swati Sharma3Indra Mani4Alok Pandya5Dinh-Toi Chu6Nhat Le Bui7Yen-Vy Nguyen Thi8Khushal Khambhati9Rupesh Maurya10Suresh Ramakrishna11Vijai Singh12Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, IndiaDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, IndiaDepartment of Biotechnology and Bioengineering, Institute of Advanced Research, Gandhinagar, Gujarat 382426, IndiaCentre of Reproductive Medicine and Andrology, Institute of Reproductive and Regenerative Biology, University of Münster, Münster, GermanyDepartment of Microbiology, Gargi College, University of Delhi, New Delhi, IndiaDepartment of Biotechnology and Bioengineering, Institute of Advanced Research, Gandhinagar, Gujarat 382426, IndiaCenter for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, VietnamCenter for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, VietnamCenter for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, VietnamDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, IndiaDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, IndiaCollege of Medicine, Hanyang University, Seoul, South Korea; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South KoreaDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, India; Corresponding author.The platform of microfluidics offers a precise control and manipulation over fluids at a small scale and therefore has gained much attention in recent times. This topic is currently applied to automation and high-throughput analysis in several areas, including extraction of DNA, RNA and proteins, gene identification, gene assembly, cloning, single-cell analysis, organs grown on chips, PCR, drug screening, toxicity testing and drug delivery. Conventional methods used for drug delivery are sometimes non-targeted leading to loss of administered drugs and reduced drug effectiveness. Recent advances in microfluidics allow precise dose-dependent delivery of a drug to a targeted location. Several microfluidics designs have been implemented to improve the precision of treatment in clinics. This review highlights currently available tools in microfluidics, designs for drug carriers, delivery methods, robotics and artificial intelligence in the field of microfluidics.http://www.sciencedirect.com/science/article/pii/S2352952023000294MicrofluidicsDrug deliveryDrug carrierMicroneedlesPrecisionRobotics |
| spellingShingle | Gargi Bhattacharjee Nisarg Gohil Malvika Shukla Swati Sharma Indra Mani Alok Pandya Dinh-Toi Chu Nhat Le Bui Yen-Vy Nguyen Thi Khushal Khambhati Rupesh Maurya Suresh Ramakrishna Vijai Singh Exploring the potential of microfluidics for next-generation drug delivery systems OpenNano Microfluidics Drug delivery Drug carrier Microneedles Precision Robotics |
| title | Exploring the potential of microfluidics for next-generation drug delivery systems |
| title_full | Exploring the potential of microfluidics for next-generation drug delivery systems |
| title_fullStr | Exploring the potential of microfluidics for next-generation drug delivery systems |
| title_full_unstemmed | Exploring the potential of microfluidics for next-generation drug delivery systems |
| title_short | Exploring the potential of microfluidics for next-generation drug delivery systems |
| title_sort | exploring the potential of microfluidics for next generation drug delivery systems |
| topic | Microfluidics Drug delivery Drug carrier Microneedles Precision Robotics |
| url | http://www.sciencedirect.com/science/article/pii/S2352952023000294 |
| work_keys_str_mv | AT gargibhattacharjee exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT nisarggohil exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT malvikashukla exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT swatisharma exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT indramani exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT alokpandya exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT dinhtoichu exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT nhatlebui exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT yenvynguyenthi exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT khushalkhambhati exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT rupeshmaurya exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT sureshramakrishna exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems AT vijaisingh exploringthepotentialofmicrofluidicsfornextgenerationdrugdeliverysystems |