Effect of Repeated Administration of ɣ-Valerolactone (GVL) and GHB in the Mouse: Neuroadaptive Changes of the GHB and GABAergic System

Effect of Repeated Administration of ɣ-Valerolactone (GVL) and GHB in the Mouse: Neuroadaptive Changes of the GHB and GABAergic System

Background: Gamma-hydroxybutyric acid (GHB) at low dosages has anxiolytic effects and promotes REM sleep and low-wave deep sleep. In the U.S., the legal form of GHB is prescribed to adults suffering from narcolepsy-associated cataplexy; the sodium salt of GHB is reserved for alcohol-addiction treatm...

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Bibliographic Details
Main Authors: Paolo Frisoni, Giorgia Corli, Sabrine Bilel, Micaela Tirri, Laura Camilla Gasparini, Letizia Alfieri, Margherita Neri, Fabio De-Giorgio, Matteo Marti
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceuticals
Subjects:
GVL
GHV
GHB
GABAergic system
drug facilitated sexual assault
date-rape drug
Online Access:https://www.mdpi.com/1424-8247/16/9/1225

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