Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis
Oxidative stress plays an important role in systemic lupus erythematosus (SLE) and especially in lupus nephritis (LN). The aim of this study was to compare redox-related biomarkers between patients with active LN, quiescent SLE (Q-SLE) and healthy controls (HC) and to explore their association with...
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MDPI AG
2023-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/8/1627 |
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| author | Lu Liu Karina de Leeuw Suzanne Arends Berber Doornbos-van der Meer Marian L. C. Bulthuis Harry van Goor Johanna Westra |
| author_facet | Lu Liu Karina de Leeuw Suzanne Arends Berber Doornbos-van der Meer Marian L. C. Bulthuis Harry van Goor Johanna Westra |
| author_sort | Lu Liu |
| collection | DOAJ |
| description | Oxidative stress plays an important role in systemic lupus erythematosus (SLE) and especially in lupus nephritis (LN). The aim of this study was to compare redox-related biomarkers between patients with active LN, quiescent SLE (Q-SLE) and healthy controls (HC) and to explore their association with clinical characteristics such as disease activity in patients. We investigated levels of plasma free thiols (R-SH, sulfhydryl groups), levels of soluble receptor for advanced glycation end products (sRAGE) and levels of malondialdehyde (MDA) in SLE patients with active LN (<i>n</i> = 23), patients with quiescent SLE (<i>n</i> = 47) and HC (<i>n</i> = 23). Data of LN patients who previously participated in Dutch lupus nephritis studies and longitudinal samples up to 36 months were analyzed. Thiol levels were lower in active LN at baseline and Q-SLE patients compared to HC. In generalized estimating equation (GEE) modelling, free thiol levels were negatively correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) over time (<i>p</i> < 0.001). sRAGE and MDA were positively correlated with the SLEDAI over time (<i>p</i> = 0.035 and <i>p</i> = 0.016, respectively). These results indicate that oxidative stress levels in LN patients are increased compared to HC and associated with SLE disease activity. Therefore, interventional therapy to restore redox homeostasis may be useful as an adjunctive therapy in the treatment of oxidative damage in SLE. |
| first_indexed | 2024-03-11T00:11:02Z |
| format | Article |
| id | doaj.art-f00dcff319d34627b9b0046fbe479b7d |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:11:02Z |
| publishDate | 2023-08-01 |
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| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-f00dcff319d34627b9b0046fbe479b7d2023-11-19T00:02:57ZengMDPI AGAntioxidants2076-39212023-08-01128162710.3390/antiox12081627Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active NephritisLu Liu0Karina de Leeuw1Suzanne Arends2Berber Doornbos-van der Meer3Marian L. C. Bulthuis4Harry van Goor5Johanna Westra6Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Pathology and Medical Biology, University Medical Centre Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Pathology and Medical Biology, University Medical Centre Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, 9713 GZ Groningen, The NetherlandsOxidative stress plays an important role in systemic lupus erythematosus (SLE) and especially in lupus nephritis (LN). The aim of this study was to compare redox-related biomarkers between patients with active LN, quiescent SLE (Q-SLE) and healthy controls (HC) and to explore their association with clinical characteristics such as disease activity in patients. We investigated levels of plasma free thiols (R-SH, sulfhydryl groups), levels of soluble receptor for advanced glycation end products (sRAGE) and levels of malondialdehyde (MDA) in SLE patients with active LN (<i>n</i> = 23), patients with quiescent SLE (<i>n</i> = 47) and HC (<i>n</i> = 23). Data of LN patients who previously participated in Dutch lupus nephritis studies and longitudinal samples up to 36 months were analyzed. Thiol levels were lower in active LN at baseline and Q-SLE patients compared to HC. In generalized estimating equation (GEE) modelling, free thiol levels were negatively correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) over time (<i>p</i> < 0.001). sRAGE and MDA were positively correlated with the SLEDAI over time (<i>p</i> = 0.035 and <i>p</i> = 0.016, respectively). These results indicate that oxidative stress levels in LN patients are increased compared to HC and associated with SLE disease activity. Therefore, interventional therapy to restore redox homeostasis may be useful as an adjunctive therapy in the treatment of oxidative damage in SLE.https://www.mdpi.com/2076-3921/12/8/1627reactive oxygen species (ROS)free thiolsmalondialdehyde (MDA)soluble receptor for advanced glycation end products (sRAGE) |
| spellingShingle | Lu Liu Karina de Leeuw Suzanne Arends Berber Doornbos-van der Meer Marian L. C. Bulthuis Harry van Goor Johanna Westra Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis Antioxidants reactive oxygen species (ROS) free thiols malondialdehyde (MDA) soluble receptor for advanced glycation end products (sRAGE) |
| title | Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis |
| title_full | Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis |
| title_fullStr | Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis |
| title_full_unstemmed | Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis |
| title_short | Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis |
| title_sort | biomarkers of oxidative stress in systemic lupus erythematosus patients with active nephritis |
| topic | reactive oxygen species (ROS) free thiols malondialdehyde (MDA) soluble receptor for advanced glycation end products (sRAGE) |
| url | https://www.mdpi.com/2076-3921/12/8/1627 |
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