Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura
Abstract Background Resting-state functional magnetic resonance imaging (Rs-fMRI) has confirmed sensorimotor network (SMN) dysfunction in migraine without aura (MwoA). However, the underlying mechanisms of SMN effective functional connectivity in MwoA remain unclear. We aimed to explore the associat...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-09-01
|
| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10194-020-01176-5 |
| _version_ | 1818383489223884800 |
|---|---|
| author | Heng-Le Wei Jing Chen Yu-Chen Chen Yu-Sheng Yu Xi Guo Gang-Ping Zhou Qing-Qing Zhou Zhen-Zhen He Lian Yang Xindao Yin Junrong Li Hong Zhang |
| author_facet | Heng-Le Wei Jing Chen Yu-Chen Chen Yu-Sheng Yu Xi Guo Gang-Ping Zhou Qing-Qing Zhou Zhen-Zhen He Lian Yang Xindao Yin Junrong Li Hong Zhang |
| author_sort | Heng-Le Wei |
| collection | DOAJ |
| description | Abstract Background Resting-state functional magnetic resonance imaging (Rs-fMRI) has confirmed sensorimotor network (SMN) dysfunction in migraine without aura (MwoA). However, the underlying mechanisms of SMN effective functional connectivity in MwoA remain unclear. We aimed to explore the association between clinical characteristics and effective functional connectivity in SMN, in interictal patients who have MwoA. Methods We used Rs-fMRI to acquire imaging data in 40 episodic patients with MwoA in the interictal phase and 34 healthy controls (HCs). Independent component analysis was used to profile the distribution of SMN and calculate the different SMN activity between the two groups. Subsequently, Granger causality analysis was used to analyze the effective functional connectivity between the SMN and other brain regions. Results Compared to the HCs, MwoA patients showed higher activity in the bilateral postcentral gyri (PoCG), but lower activity in the left midcingulate cortex (MCC). Moreover, MwoA patients showed decreased effective functional connectivity from the SMN to left middle temporal gyrus, right putamen, left insula and bilateral precuneus, but increased effective functional connectivity to the right paracentral lobule. There was also significant effective functional connectivity from the primary visual cortex, right cuneus and right putamen to the SMN. In the interictal period, there was positive correlation between the activity of the right PoCG and the frequency of headache. The disease duration was positively correlated with abnormal effective functional connectivity from the left PoCG to right precuneus. In addition, the headache impact scores were negatively correlated with abnormal effective functional connectivity from the left MCC to right paracentral lobule, as well as from the right precuneus to left PoCG. Conclusions These differential, resting-state functional activities of the SMN in episodic MwoA may contribute to the understanding of migraine-related intra- and internetwork imbalances associated with nociceptive regulation and chronification. |
| first_indexed | 2024-12-14T03:07:11Z |
| format | Article |
| id | doaj.art-f010eacac9044f9bb091ee3155e9f9d9 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-14T03:07:11Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-f010eacac9044f9bb091ee3155e9f9d92022-12-21T23:19:22ZengBMCThe Journal of Headache and Pain1129-23691129-23772020-09-012111910.1186/s10194-020-01176-5Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without auraHeng-Le Wei0Jing Chen1Yu-Chen Chen2Yu-Sheng Yu3Xi Guo4Gang-Ping Zhou5Qing-Qing Zhou6Zhen-Zhen He7Lian Yang8Xindao Yin9Junrong Li10Hong Zhang11Department of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Neurology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Neurology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical UniversityAbstract Background Resting-state functional magnetic resonance imaging (Rs-fMRI) has confirmed sensorimotor network (SMN) dysfunction in migraine without aura (MwoA). However, the underlying mechanisms of SMN effective functional connectivity in MwoA remain unclear. We aimed to explore the association between clinical characteristics and effective functional connectivity in SMN, in interictal patients who have MwoA. Methods We used Rs-fMRI to acquire imaging data in 40 episodic patients with MwoA in the interictal phase and 34 healthy controls (HCs). Independent component analysis was used to profile the distribution of SMN and calculate the different SMN activity between the two groups. Subsequently, Granger causality analysis was used to analyze the effective functional connectivity between the SMN and other brain regions. Results Compared to the HCs, MwoA patients showed higher activity in the bilateral postcentral gyri (PoCG), but lower activity in the left midcingulate cortex (MCC). Moreover, MwoA patients showed decreased effective functional connectivity from the SMN to left middle temporal gyrus, right putamen, left insula and bilateral precuneus, but increased effective functional connectivity to the right paracentral lobule. There was also significant effective functional connectivity from the primary visual cortex, right cuneus and right putamen to the SMN. In the interictal period, there was positive correlation between the activity of the right PoCG and the frequency of headache. The disease duration was positively correlated with abnormal effective functional connectivity from the left PoCG to right precuneus. In addition, the headache impact scores were negatively correlated with abnormal effective functional connectivity from the left MCC to right paracentral lobule, as well as from the right precuneus to left PoCG. Conclusions These differential, resting-state functional activities of the SMN in episodic MwoA may contribute to the understanding of migraine-related intra- and internetwork imbalances associated with nociceptive regulation and chronification.http://link.springer.com/article/10.1186/s10194-020-01176-5Magnetic resonance imagingMigraineSensorimotor networkEffective functional connectivity |
| spellingShingle | Heng-Le Wei Jing Chen Yu-Chen Chen Yu-Sheng Yu Xi Guo Gang-Ping Zhou Qing-Qing Zhou Zhen-Zhen He Lian Yang Xindao Yin Junrong Li Hong Zhang Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura The Journal of Headache and Pain Magnetic resonance imaging Migraine Sensorimotor network Effective functional connectivity |
| title | Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura |
| title_full | Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura |
| title_fullStr | Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura |
| title_full_unstemmed | Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura |
| title_short | Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura |
| title_sort | impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura |
| topic | Magnetic resonance imaging Migraine Sensorimotor network Effective functional connectivity |
| url | http://link.springer.com/article/10.1186/s10194-020-01176-5 |
| work_keys_str_mv | AT henglewei impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT jingchen impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT yuchenchen impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT yushengyu impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT xiguo impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT gangpingzhou impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT qingqingzhou impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT zhenzhenhe impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT lianyang impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT xindaoyin impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT junrongli impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura AT hongzhang impairedeffectivefunctionalconnectivityofthesensorimotornetworkininterictalepisodicmigraineurswithoutaura |