Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.

Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.

Foot-and-Mouth Disease Virus (FMDV) is a picornavirus that infects cloven-hoofed animals and leads to severe losses in livestock production. In the case of an FMD outbreak, emergency vaccination requires at least 7 days to trigger an effective immune response. There are currently no approved inhibit...

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Bibliographic Details
Main Authors: Ryan C Durk, Kamalendra Singh, Ceili A Cornelison, Devendra K Rai, Kayla B Matzek, Maxwell D Leslie, Elizabeth Schafer, Bruno Marchand, Adeyemi Adedeji, Eleftherios Michailidis, Christopher A Dorst, Jennifer Moran, Christie Pautler, Luis L Rodriguez, Mark A McIntosh, Elizabeth Rieder, Stefan G Sarafianos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3006429?pdf=render

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