The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned?
Acute respiratory distress syndrome (ARDS) is a well-defined clinical entity characterized by the acute onset of diffuse pulmonary injury and hypoxemia not explained by fluid overload. The COVID-19 pandemic brought about an unprecedented volume of patients with ARDS and challenged our understanding...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/13/7/1833 |
| _version_ | 1797212465974476800 |
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| author | Rebecca L. Kummer John J. Marini |
| author_facet | Rebecca L. Kummer John J. Marini |
| author_sort | Rebecca L. Kummer |
| collection | DOAJ |
| description | Acute respiratory distress syndrome (ARDS) is a well-defined clinical entity characterized by the acute onset of diffuse pulmonary injury and hypoxemia not explained by fluid overload. The COVID-19 pandemic brought about an unprecedented volume of patients with ARDS and challenged our understanding and clinical approach to treatment of this clinical syndrome. Unique to COVID-19 ARDS is the disruption and dysregulation of the pulmonary vascular compartment caused by the SARS-CoV-2 virus, which is a significant cause of hypoxemia in these patients. As a result, gas exchange does not necessarily correlate with respiratory system compliance and mechanics in COVID-19 ARDS as it does with other etiologies. The purpose of this review is to relate the mechanics of COVID-19 ARDS to its underlying pathophysiologic mechanisms and outline the lessons we have learned in the management of this clinic syndrome. |
| first_indexed | 2024-04-24T10:42:49Z |
| format | Article |
| id | doaj.art-f014baf25b89400a83d4fef03f52ce65 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T10:42:49Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f014baf25b89400a83d4fef03f52ce652024-04-12T13:20:46ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01137183310.3390/jcm13071833The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned?Rebecca L. Kummer0John J. Marini1Department of Pulmonary and Critical Care Medicine, University of Minnesota School of Medicine, Minneapolis, MN 55455, USADepartment of Pulmonary and Critical Care Medicine, Regions Hospital, St. Paul, MN 55101, USAAcute respiratory distress syndrome (ARDS) is a well-defined clinical entity characterized by the acute onset of diffuse pulmonary injury and hypoxemia not explained by fluid overload. The COVID-19 pandemic brought about an unprecedented volume of patients with ARDS and challenged our understanding and clinical approach to treatment of this clinical syndrome. Unique to COVID-19 ARDS is the disruption and dysregulation of the pulmonary vascular compartment caused by the SARS-CoV-2 virus, which is a significant cause of hypoxemia in these patients. As a result, gas exchange does not necessarily correlate with respiratory system compliance and mechanics in COVID-19 ARDS as it does with other etiologies. The purpose of this review is to relate the mechanics of COVID-19 ARDS to its underlying pathophysiologic mechanisms and outline the lessons we have learned in the management of this clinic syndrome.https://www.mdpi.com/2077-0383/13/7/1833COVID-19ARDSPEEPVILIPSILI |
| spellingShingle | Rebecca L. Kummer John J. Marini The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned? Journal of Clinical Medicine COVID-19 ARDS PEEP VILI PSILI |
| title | The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned? |
| title_full | The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned? |
| title_fullStr | The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned? |
| title_full_unstemmed | The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned? |
| title_short | The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned? |
| title_sort | respiratory mechanics of covid 19 acute respiratory distress syndrome lessons learned |
| topic | COVID-19 ARDS PEEP VILI PSILI |
| url | https://www.mdpi.com/2077-0383/13/7/1833 |
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