SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations

SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations

Summary: The small ubiquitin-like modifier (SUMO) protease SENP6 disassembles SUMO chains from cellular substrate proteins. We use a proteomic method to identify putative SENP6 substrates based on increased apparent molecular weight after SENP6 depletion. Proteins of the lamin family of intermediate...

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Bibliographic Details
Main Authors: Magda Liczmanska, Michael H. Tatham, Barbara Mojsa, Ania Eugui-Anta, Alejandro Rojas-Fernandez, Adel F.M. Ibrahim, Ronald T. Hay
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009713

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