N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain

N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain

We determined the effect of N-acetylcysteine (NAC) on the expression of the phosphorylated p38 (p-p38) protein and superoxide anion generation (SAG), two important players in the processing of neuropathic pain, in the lumbosacral spinal cord of rats with chronic constriction injury (CCI)-induced neu...

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Bibliographic Details
Main Authors: A. Horst, J.A. de Souza, M.C.Q. Santos, A.P.K. Riffel, C. Kolberg, M.F.M. Ribeiro, L.S. de Fraga, W.A. Partata
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Sciatic functional index
Chronic constriction
Sciatic nerve
Mitogen-activated protein kinase
Antinociception
Mechanical threshold
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200605&lng=en&tlng=en

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