Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain
Although optimizing decisions between drives to avoid pain and to obtain reward are critical for survival, understanding the neuronal circuit activity that regulates choice during approach-avoidance conflicts is limited. Here, we recorded neuronal activity in the infralimbic (IL) cortex and nucleus...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-05-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717306022 |
| _version_ | 1819049977259753472 |
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| author | Neil Schwartz Catriona Miller Howard L. Fields |
| author_facet | Neil Schwartz Catriona Miller Howard L. Fields |
| author_sort | Neil Schwartz |
| collection | DOAJ |
| description | Although optimizing decisions between drives to avoid pain and to obtain reward are critical for survival, understanding the neuronal circuit activity that regulates choice during approach-avoidance conflicts is limited. Here, we recorded neuronal activity in the infralimbic (IL) cortex and nucleus accumbens (NAc) during an approach-avoidance task. In this task, disruption of approach by a pain-predictive cue (PPC-avoidance) is extinguished by experience and reinstated in a model of chronic pain. In the IL-NAc circuit, the activity of distinct subpopulations of neurons predicts the extent of PPC-avoidance observed. Furthermore, chemogenetic and optogenetic manipulations establish that IL-NAc circuitry regulates PPC-avoidance behavior. Our results indicate that IL-NAc circuitry is engaged during approach-avoidance conflicts, and modifications of this circuit by experience and chronic pain determine whether approach or avoidance occurs. |
| first_indexed | 2024-12-21T11:40:43Z |
| format | Article |
| id | doaj.art-f017138f9c734b76b460956de88078fc |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-21T11:40:43Z |
| publishDate | 2017-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-f017138f9c734b76b460956de88078fc2022-12-21T19:05:19ZengElsevierCell Reports2211-12472017-05-011981522153110.1016/j.celrep.2017.04.073Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic PainNeil Schwartz0Catriona Miller1Howard L. Fields2Department of Neurology, the Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USADepartment of Neurology, the Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USADepartment of Neurology, the Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USAAlthough optimizing decisions between drives to avoid pain and to obtain reward are critical for survival, understanding the neuronal circuit activity that regulates choice during approach-avoidance conflicts is limited. Here, we recorded neuronal activity in the infralimbic (IL) cortex and nucleus accumbens (NAc) during an approach-avoidance task. In this task, disruption of approach by a pain-predictive cue (PPC-avoidance) is extinguished by experience and reinstated in a model of chronic pain. In the IL-NAc circuit, the activity of distinct subpopulations of neurons predicts the extent of PPC-avoidance observed. Furthermore, chemogenetic and optogenetic manipulations establish that IL-NAc circuitry regulates PPC-avoidance behavior. Our results indicate that IL-NAc circuitry is engaged during approach-avoidance conflicts, and modifications of this circuit by experience and chronic pain determine whether approach or avoidance occurs.http://www.sciencedirect.com/science/article/pii/S2211124717306022approach-avoidancepainchronic paininfralimbicaccumbensventral striatummotivationchoicevmPFC |
| spellingShingle | Neil Schwartz Catriona Miller Howard L. Fields Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain Cell Reports approach-avoidance pain chronic pain infralimbic accumbens ventral striatum motivation choice vmPFC |
| title | Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain |
| title_full | Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain |
| title_fullStr | Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain |
| title_full_unstemmed | Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain |
| title_short | Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain |
| title_sort | cortico accumbens regulation of approach avoidance behavior is modified by experience and chronic pain |
| topic | approach-avoidance pain chronic pain infralimbic accumbens ventral striatum motivation choice vmPFC |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717306022 |
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