Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study
<p>Abstract</p> <p>Background</p> <p>The association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a case-control study in a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-08-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/10/242 |
| _version_ | 1818690194104123392 |
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| author | Adjorlolo-Johnson Georgette Unger Elizabeth R Boni-Ouattara Edith Touré-Coulibaly Kadidiata Maurice Chantal Vernon Suzanne D Sissoko Marcel Greenberg Alan E Wiktor Stefan Z Chorba Terence L |
| author_facet | Adjorlolo-Johnson Georgette Unger Elizabeth R Boni-Ouattara Edith Touré-Coulibaly Kadidiata Maurice Chantal Vernon Suzanne D Sissoko Marcel Greenberg Alan E Wiktor Stefan Z Chorba Terence L |
| author_sort | Adjorlolo-Johnson Georgette |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a case-control study in a West African population to assess the relationship between HIV infection and invasive cervical cancer, taking into account HPV infection and other potential risk factors for cervical cancer.</p> <p>Methods</p> <p>Women with invasive cervical cancer (cases) or normal cervical cytology (controls) were recruited in a hospital-based case-control study in Abidjan, Côte d'Ivoire. Odds ratios and 95% confidence intervals (CI) were estimated in logistic regression analyses controlling for important cofactors.</p> <p>Results</p> <p>HIV infection was noted in 22/132 (16.7%) cases and 10/120 (8.3%) controls (p = 0.048). High-risk HPV infection was detected in cervical tumor samples from 89.4% of case-participants and in cervical cytology samples in 31.1% of control-participants. In logistic regression analysis, HIV infection was associated with cervical cancer in women with HPV (OR 3.4; 95% CI 1.1-10.8). Among women aged ≤ 40 years, risk factors for cervical cancer were high-risk HPV infection (OR 49.3; 95% CI 8.2-295.7); parity > 2 (OR 7.0; 95% CI 1.9-25.7) and HIV infection (OR 4.5; 95% CI 1.5-13.6). Among women aged > 40 years, high-risk HPV infection (OR 23.5; 95% CI 9.1-60.6) and parity > 2 (OR 5.5; 95% CI 2.3-13.4), but association with HIV infection was not statistically significant.</p> <p>Conclusions</p> <p>These data support the hypothesis that HIV infection is a cofactor for cervical cancer in women with HPV infection, and, as in all populations, the need for promoting cervical screening in populations with high prevalence of HIV infection.</p> |
| first_indexed | 2024-12-17T12:22:07Z |
| format | Article |
| id | doaj.art-f017d8d7ed334cdba3057639cf0ac2ae |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-17T12:22:07Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj.art-f017d8d7ed334cdba3057639cf0ac2ae2022-12-21T21:48:56ZengBMCBMC Infectious Diseases1471-23342010-08-0110124210.1186/1471-2334-10-242Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control studyAdjorlolo-Johnson GeorgetteUnger Elizabeth RBoni-Ouattara EdithTouré-Coulibaly KadidiataMaurice ChantalVernon Suzanne DSissoko MarcelGreenberg Alan EWiktor Stefan ZChorba Terence L<p>Abstract</p> <p>Background</p> <p>The association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a case-control study in a West African population to assess the relationship between HIV infection and invasive cervical cancer, taking into account HPV infection and other potential risk factors for cervical cancer.</p> <p>Methods</p> <p>Women with invasive cervical cancer (cases) or normal cervical cytology (controls) were recruited in a hospital-based case-control study in Abidjan, Côte d'Ivoire. Odds ratios and 95% confidence intervals (CI) were estimated in logistic regression analyses controlling for important cofactors.</p> <p>Results</p> <p>HIV infection was noted in 22/132 (16.7%) cases and 10/120 (8.3%) controls (p = 0.048). High-risk HPV infection was detected in cervical tumor samples from 89.4% of case-participants and in cervical cytology samples in 31.1% of control-participants. In logistic regression analysis, HIV infection was associated with cervical cancer in women with HPV (OR 3.4; 95% CI 1.1-10.8). Among women aged ≤ 40 years, risk factors for cervical cancer were high-risk HPV infection (OR 49.3; 95% CI 8.2-295.7); parity > 2 (OR 7.0; 95% CI 1.9-25.7) and HIV infection (OR 4.5; 95% CI 1.5-13.6). Among women aged > 40 years, high-risk HPV infection (OR 23.5; 95% CI 9.1-60.6) and parity > 2 (OR 5.5; 95% CI 2.3-13.4), but association with HIV infection was not statistically significant.</p> <p>Conclusions</p> <p>These data support the hypothesis that HIV infection is a cofactor for cervical cancer in women with HPV infection, and, as in all populations, the need for promoting cervical screening in populations with high prevalence of HIV infection.</p>http://www.biomedcentral.com/1471-2334/10/242 |
| spellingShingle | Adjorlolo-Johnson Georgette Unger Elizabeth R Boni-Ouattara Edith Touré-Coulibaly Kadidiata Maurice Chantal Vernon Suzanne D Sissoko Marcel Greenberg Alan E Wiktor Stefan Z Chorba Terence L Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study BMC Infectious Diseases |
| title | Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study |
| title_full | Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study |
| title_fullStr | Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study |
| title_full_unstemmed | Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study |
| title_short | Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study |
| title_sort | assessing the relationship between hiv infection and cervical cancer in cote d ivoire a case control study |
| url | http://www.biomedcentral.com/1471-2334/10/242 |
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