Estimation of tumor necrosis factor-α in chronic periodontitis and its co-relation with preterm gestation: A Clinico biochemical study
Background: The aim of this study was to estimate the levels of tumor necrosis factor-α (TNF-α) in serum of healthy, term gestation women and periodontitis affected pre-term gestation women and to find out the association between TNF-α levels, gestational age and different periodontal variables in s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Journal of Orofacial Sciences |
| Subjects: | |
| Online Access: | http://www.jofs.in/article.asp?issn=0975-8844;year=2012;volume=4;issue=2;spage=108;epage=113;aulast=Reddy |
| _version_ | 1818535555287220224 |
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| author | N Ravindra Reddy D S Madhu Babu Vinathi Reddy N Sarath C Venkat Subba Reddy A Kishore Kumar |
| author_facet | N Ravindra Reddy D S Madhu Babu Vinathi Reddy N Sarath C Venkat Subba Reddy A Kishore Kumar |
| author_sort | N Ravindra Reddy |
| collection | DOAJ |
| description | Background: The aim of this study was to estimate the levels of tumor necrosis factor-α (TNF-α) in serum of healthy, term gestation women and periodontitis affected pre-term gestation women and to find out the association between TNF-α levels, gestational age and different periodontal variables in serum. Materials and Methods: Clinical parameters, including pocket depth, Russel′s periodontal indexes were recorded from 36 subjects divided into two groups based on presence of pocket beyond 5 mm and gestational age above or below 36 weeks. Blood samples from all 36 subjects were obtained from the fetal side of the umbilical cord of the term and pre-term gestation infants at delivery. Serum was separated from the collected blood samples and TNF-α from the resultant serum was quantified using enzyme linked immunosorbent assay essay. Results: The mean amounts of TNF-α was significantly higher in Group-II when compared to Group-I, which was statistically significant ( P < 0.001). Positive correlation was found between TNF-α concentration and Gestational age ( P < 0.001), Russel′s periodontal index ( P < 0.001), Pocket depth ( P < 0.001) which were statistically significant. A positive correlation was found between pocket depth, Russel′s periodontal index and gestational age ( R = −0.69, P < 0.001), ( R = −0.71, P < 0.001) i.e., when pocket depth (beyond 4 mm or above) and Russel′s periodontal index increase, estimated gestational age shows a steady decline. Conclusion: TNF-α concentrations correlated positively with the extent of periodontal destruction, Russel′s periodontal index score and gestational age, With increase in amount of periodontal destruction, there is a substantial increase in clinical parameters and TNF-α level in serum, which is inversely related to premature gestation. |
| first_indexed | 2024-12-11T18:26:27Z |
| format | Article |
| id | doaj.art-f019d10022fa437793808e8fb2819927 |
| institution | Directory Open Access Journal |
| issn | 0975-8844 |
| language | English |
| last_indexed | 2024-12-11T18:26:27Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Orofacial Sciences |
| spelling | doaj.art-f019d10022fa437793808e8fb28199272022-12-22T00:55:04ZengWolters Kluwer Medknow PublicationsJournal of Orofacial Sciences0975-88442012-01-014210811310.4103/0975-8844.106201Estimation of tumor necrosis factor-α in chronic periodontitis and its co-relation with preterm gestation: A Clinico biochemical studyN Ravindra ReddyD S Madhu BabuVinathi ReddyN SarathC Venkat Subba ReddyA Kishore KumarBackground: The aim of this study was to estimate the levels of tumor necrosis factor-α (TNF-α) in serum of healthy, term gestation women and periodontitis affected pre-term gestation women and to find out the association between TNF-α levels, gestational age and different periodontal variables in serum. Materials and Methods: Clinical parameters, including pocket depth, Russel′s periodontal indexes were recorded from 36 subjects divided into two groups based on presence of pocket beyond 5 mm and gestational age above or below 36 weeks. Blood samples from all 36 subjects were obtained from the fetal side of the umbilical cord of the term and pre-term gestation infants at delivery. Serum was separated from the collected blood samples and TNF-α from the resultant serum was quantified using enzyme linked immunosorbent assay essay. Results: The mean amounts of TNF-α was significantly higher in Group-II when compared to Group-I, which was statistically significant ( P < 0.001). Positive correlation was found between TNF-α concentration and Gestational age ( P < 0.001), Russel′s periodontal index ( P < 0.001), Pocket depth ( P < 0.001) which were statistically significant. A positive correlation was found between pocket depth, Russel′s periodontal index and gestational age ( R = −0.69, P < 0.001), ( R = −0.71, P < 0.001) i.e., when pocket depth (beyond 4 mm or above) and Russel′s periodontal index increase, estimated gestational age shows a steady decline. Conclusion: TNF-α concentrations correlated positively with the extent of periodontal destruction, Russel′s periodontal index score and gestational age, With increase in amount of periodontal destruction, there is a substantial increase in clinical parameters and TNF-α level in serum, which is inversely related to premature gestation.http://www.jofs.in/article.asp?issn=0975-8844;year=2012;volume=4;issue=2;spage=108;epage=113;aulast=ReddyChronic periodontitis, pre-term gestational age, tumor necrosis factor-α in serum |
| spellingShingle | N Ravindra Reddy D S Madhu Babu Vinathi Reddy N Sarath C Venkat Subba Reddy A Kishore Kumar Estimation of tumor necrosis factor-α in chronic periodontitis and its co-relation with preterm gestation: A Clinico biochemical study Journal of Orofacial Sciences Chronic periodontitis, pre-term gestational age, tumor necrosis factor-α in serum |
| title | Estimation of tumor necrosis factor-α in chronic periodontitis and its co-relation with preterm gestation: A Clinico biochemical study |
| title_full | Estimation of tumor necrosis factor-α in chronic periodontitis and its co-relation with preterm gestation: A Clinico biochemical study |
| title_fullStr | Estimation of tumor necrosis factor-α in chronic periodontitis and its co-relation with preterm gestation: A Clinico biochemical study |
| title_full_unstemmed | Estimation of tumor necrosis factor-α in chronic periodontitis and its co-relation with preterm gestation: A Clinico biochemical study |
| title_short | Estimation of tumor necrosis factor-α in chronic periodontitis and its co-relation with preterm gestation: A Clinico biochemical study |
| title_sort | estimation of tumor necrosis factor α in chronic periodontitis and its co relation with preterm gestation a clinico biochemical study |
| topic | Chronic periodontitis, pre-term gestational age, tumor necrosis factor-α in serum |
| url | http://www.jofs.in/article.asp?issn=0975-8844;year=2012;volume=4;issue=2;spage=108;epage=113;aulast=Reddy |
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