Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo
The Democratic Republic of Congo (DRC) experienced a confined rural outbreak of Ebola virus disease (EVD) with 69 reported cases from July to October 2014. Understanding the transmission dynamics during the outbreak can provide important information for anticipating and controlling future EVD epidem...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2015-11-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/1418.pdf |
| _version_ | 1797418429243719680 |
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| author | Christian L. Althaus |
| author_facet | Christian L. Althaus |
| author_sort | Christian L. Althaus |
| collection | DOAJ |
| description | The Democratic Republic of Congo (DRC) experienced a confined rural outbreak of Ebola virus disease (EVD) with 69 reported cases from July to October 2014. Understanding the transmission dynamics during the outbreak can provide important information for anticipating and controlling future EVD epidemics. I fitted an EVD transmission model to previously published data of this outbreak and estimated the basic reproduction number R0 = 5.2 (95% CI [4.0–6.7]). The model suggests that the net reproduction number Rt fell below unity 28 days (95% CI [25–34] days) after the onset of symptoms in the index case. This study adds to previous epidemiological descriptions of the 2014 EVD outbreak in DRC, and is consistent with the notion that a rapid implementation of control interventions helped reduce further spread. |
| first_indexed | 2024-03-09T06:33:31Z |
| format | Article |
| id | doaj.art-f019e95bca51456cbee311c153d3b7e9 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:33:31Z |
| publishDate | 2015-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-f019e95bca51456cbee311c153d3b7e92023-12-03T11:02:52ZengPeerJ Inc.PeerJ2167-83592015-11-013e141810.7717/peerj.1418Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of CongoChristian L. Althaus0Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, SwitzerlandThe Democratic Republic of Congo (DRC) experienced a confined rural outbreak of Ebola virus disease (EVD) with 69 reported cases from July to October 2014. Understanding the transmission dynamics during the outbreak can provide important information for anticipating and controlling future EVD epidemics. I fitted an EVD transmission model to previously published data of this outbreak and estimated the basic reproduction number R0 = 5.2 (95% CI [4.0–6.7]). The model suggests that the net reproduction number Rt fell below unity 28 days (95% CI [25–34] days) after the onset of symptoms in the index case. This study adds to previous epidemiological descriptions of the 2014 EVD outbreak in DRC, and is consistent with the notion that a rapid implementation of control interventions helped reduce further spread.https://peerj.com/articles/1418.pdfBasic reproduction numberMathematical modelEbola virus diseaseOutbreakDemocratic Republic of Congo |
| spellingShingle | Christian L. Althaus Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo PeerJ Basic reproduction number Mathematical model Ebola virus disease Outbreak Democratic Republic of Congo |
| title | Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo |
| title_full | Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo |
| title_fullStr | Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo |
| title_full_unstemmed | Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo |
| title_short | Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo |
| title_sort | rapid drop in the reproduction number during the ebola outbreak in the democratic republic of congo |
| topic | Basic reproduction number Mathematical model Ebola virus disease Outbreak Democratic Republic of Congo |
| url | https://peerj.com/articles/1418.pdf |
| work_keys_str_mv | AT christianlalthaus rapiddropinthereproductionnumberduringtheebolaoutbreakinthedemocraticrepublicofcongo |