Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature
Adenoid cystic carcinoma of the external auditory canal is very rare tumour. Its course is mainly indolent, and is characterised by intracranial extension, high rates of loco-regional relapse, and distant metastasis, which culminates in a slow detrimental disease course, eventually leading to death....
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621921000788 |
| _version_ | 1819099091457540096 |
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| author | Nuria Mederos Jeremy Jankovic Ruth Gabriela Herrera Gomez Vincent Dunet Valerie Cristina |
| author_facet | Nuria Mederos Jeremy Jankovic Ruth Gabriela Herrera Gomez Vincent Dunet Valerie Cristina |
| author_sort | Nuria Mederos |
| collection | DOAJ |
| description | Adenoid cystic carcinoma of the external auditory canal is very rare tumour. Its course is mainly indolent, and is characterised by intracranial extension, high rates of loco-regional relapse, and distant metastasis, which culminates in a slow detrimental disease course, eventually leading to death. The main therapeutic modalities are local therapies such as surgery and/or radiotherapy. Systemic treatment has never achieved good clinical outcomes in this setting. Here, we describe the case report of a 50-year-old female, diagnosed with an adenoid cystic carcinoma of the right external auditory canal in 2003. The patient developed multiples recurrences, including an extensive intracerebral progression associated with radio necrosis, for which systemic therapy with bevacizumab and epirubicin was initiated. This achieved an intracerebral partial response with clinical benefit, allowing the rapid tapering of corticosteroid treatment. This case report highlights epirubicin in combination with bevacizumab as a therapeutic option for heavily treated patients with adenoid cystic carcinoma and intracranial involvement. |
| first_indexed | 2024-12-22T00:41:22Z |
| format | Article |
| id | doaj.art-f01acb1ee18c4000bb2e24190f868580 |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-12-22T00:41:22Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-f01acb1ee18c4000bb2e24190f8685802022-12-21T18:44:40ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192021-12-014100130Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literatureNuria Mederos0Jeremy Jankovic1Ruth Gabriela Herrera Gomez2Vincent Dunet3Valerie Cristina4Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland; Corresponding author.Department of Oncology, Lausanne University Hospital, Lausanne, SwitzerlandDepartment of Oncology, Lausanne University Hospital, Lausanne, SwitzerlandDepartment of Diagnostic and Interventional radiology, Lausanne University Hospital, Lausanne, SwitzerlandDepartment of Oncology, Lausanne University Hospital, Lausanne, SwitzerlandAdenoid cystic carcinoma of the external auditory canal is very rare tumour. Its course is mainly indolent, and is characterised by intracranial extension, high rates of loco-regional relapse, and distant metastasis, which culminates in a slow detrimental disease course, eventually leading to death. The main therapeutic modalities are local therapies such as surgery and/or radiotherapy. Systemic treatment has never achieved good clinical outcomes in this setting. Here, we describe the case report of a 50-year-old female, diagnosed with an adenoid cystic carcinoma of the right external auditory canal in 2003. The patient developed multiples recurrences, including an extensive intracerebral progression associated with radio necrosis, for which systemic therapy with bevacizumab and epirubicin was initiated. This achieved an intracerebral partial response with clinical benefit, allowing the rapid tapering of corticosteroid treatment. This case report highlights epirubicin in combination with bevacizumab as a therapeutic option for heavily treated patients with adenoid cystic carcinoma and intracranial involvement.http://www.sciencedirect.com/science/article/pii/S2666621921000788External auditory canalAdenoid cystic carcinomaEpirubicinBevacizumabCase report |
| spellingShingle | Nuria Mederos Jeremy Jankovic Ruth Gabriela Herrera Gomez Vincent Dunet Valerie Cristina Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature Current Problems in Cancer: Case Reports External auditory canal Adenoid cystic carcinoma Epirubicin Bevacizumab Case report |
| title | Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature |
| title_full | Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature |
| title_fullStr | Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature |
| title_full_unstemmed | Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature |
| title_short | Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature |
| title_sort | intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal a case report and review of the literature |
| topic | External auditory canal Adenoid cystic carcinoma Epirubicin Bevacizumab Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2666621921000788 |
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