Antimicrobial Susceptibility of <i>Streptococcus suis</i> Isolated from Diseased Pigs in Thailand, 2018–2020
<i>Streptococcus suis</i> is a porcine and zoonotic pathogen that causes severe systemic infection in humans and pigs. The treatment of <i>S. suis</i> infection relies on antibiotics; however, antimicrobial resistance (AMR) is an urgent global problem, pushing research attent...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/3/410 |
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| author | Kamonwan Lunha Wiyada Chumpol Sukuma Samngamnim Surasak Jiemsup Pornchalit Assavacheep Suganya Yongkiettrakul |
| author_facet | Kamonwan Lunha Wiyada Chumpol Sukuma Samngamnim Surasak Jiemsup Pornchalit Assavacheep Suganya Yongkiettrakul |
| author_sort | Kamonwan Lunha |
| collection | DOAJ |
| description | <i>Streptococcus suis</i> is a porcine and zoonotic pathogen that causes severe systemic infection in humans and pigs. The treatment of <i>S. suis</i> infection relies on antibiotics; however, antimicrobial resistance (AMR) is an urgent global problem, pushing research attention on the surveillance of antibiotic-resistant <i>S. suis</i> to the fore. This study investigated the antimicrobial susceptibility of 246 <i>S. suis</i> strains isolated from diseased pigs in Thailand from 2018–2020. The major sources of <i>S. suis</i> strains were lung and brain tissues. PCR-based serotyping demonstrated that the most abundant serotype was serotype 2 or ½, followed by serotypes 29, 8, 9, and 21. To the best of our knowledge, this is the first report describing the distribution of AMR <i>S. suis</i> serotype 29 in diseased pigs. The antimicrobial susceptibility test was performed to determine the minimum inhibitory concentrations of 35 antimicrobial agents. The results showed that important antimicrobial agents for human use, amoxicillin/clavulanic acid, daptomycin, ertapenem, meropenem, and vancomycin, were the most effective drugs. However, a slight decrease in the number of <i>S. suis</i> strains susceptible to amoxicillin/clavulanic acid and vancomycin raised awareness of the AMR problem in the future. The data indicated a tendency of reduced efficacy of available veterinary medicines, including ampicillin, cefepime, cefotaxime, ceftiofur, ceftriaxone, chloramphenicol, florfenicol, gentamicin, penicillin, and tiamulin, for the treatment of <i>S. suis</i> infection, thus emphasizing the importance of the prudent use of antibiotics. The widespread of multidrug-resistant <i>S. suis</i> strains was identified in all serotypes and from different time periods and different regions of the country, confirming the emergence of the AMR problem in the diseased pig-isolated <i>S. suis</i> population. |
| first_indexed | 2024-03-09T20:12:10Z |
| format | Article |
| id | doaj.art-f01f3390b51e4dc2b8ed90549ca7abf9 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T20:12:10Z |
| publishDate | 2022-03-01 |
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| series | Antibiotics |
| spelling | doaj.art-f01f3390b51e4dc2b8ed90549ca7abf92023-11-24T00:12:11ZengMDPI AGAntibiotics2079-63822022-03-0111341010.3390/antibiotics11030410Antimicrobial Susceptibility of <i>Streptococcus suis</i> Isolated from Diseased Pigs in Thailand, 2018–2020Kamonwan Lunha0Wiyada Chumpol1Sukuma Samngamnim2Surasak Jiemsup3Pornchalit Assavacheep4Suganya Yongkiettrakul5National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani 12120, ThailandNational Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani 12120, ThailandDepartment of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, ThailandNational Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani 12120, ThailandDepartment of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, ThailandNational Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani 12120, Thailand<i>Streptococcus suis</i> is a porcine and zoonotic pathogen that causes severe systemic infection in humans and pigs. The treatment of <i>S. suis</i> infection relies on antibiotics; however, antimicrobial resistance (AMR) is an urgent global problem, pushing research attention on the surveillance of antibiotic-resistant <i>S. suis</i> to the fore. This study investigated the antimicrobial susceptibility of 246 <i>S. suis</i> strains isolated from diseased pigs in Thailand from 2018–2020. The major sources of <i>S. suis</i> strains were lung and brain tissues. PCR-based serotyping demonstrated that the most abundant serotype was serotype 2 or ½, followed by serotypes 29, 8, 9, and 21. To the best of our knowledge, this is the first report describing the distribution of AMR <i>S. suis</i> serotype 29 in diseased pigs. The antimicrobial susceptibility test was performed to determine the minimum inhibitory concentrations of 35 antimicrobial agents. The results showed that important antimicrobial agents for human use, amoxicillin/clavulanic acid, daptomycin, ertapenem, meropenem, and vancomycin, were the most effective drugs. However, a slight decrease in the number of <i>S. suis</i> strains susceptible to amoxicillin/clavulanic acid and vancomycin raised awareness of the AMR problem in the future. The data indicated a tendency of reduced efficacy of available veterinary medicines, including ampicillin, cefepime, cefotaxime, ceftiofur, ceftriaxone, chloramphenicol, florfenicol, gentamicin, penicillin, and tiamulin, for the treatment of <i>S. suis</i> infection, thus emphasizing the importance of the prudent use of antibiotics. The widespread of multidrug-resistant <i>S. suis</i> strains was identified in all serotypes and from different time periods and different regions of the country, confirming the emergence of the AMR problem in the diseased pig-isolated <i>S. suis</i> population.https://www.mdpi.com/2079-6382/11/3/410antimicrobial resistanceAMRmultidrug resistanceMDRsurveillancezoonosis |
| spellingShingle | Kamonwan Lunha Wiyada Chumpol Sukuma Samngamnim Surasak Jiemsup Pornchalit Assavacheep Suganya Yongkiettrakul Antimicrobial Susceptibility of <i>Streptococcus suis</i> Isolated from Diseased Pigs in Thailand, 2018–2020 Antibiotics antimicrobial resistance AMR multidrug resistance MDR surveillance zoonosis |
| title | Antimicrobial Susceptibility of <i>Streptococcus suis</i> Isolated from Diseased Pigs in Thailand, 2018–2020 |
| title_full | Antimicrobial Susceptibility of <i>Streptococcus suis</i> Isolated from Diseased Pigs in Thailand, 2018–2020 |
| title_fullStr | Antimicrobial Susceptibility of <i>Streptococcus suis</i> Isolated from Diseased Pigs in Thailand, 2018–2020 |
| title_full_unstemmed | Antimicrobial Susceptibility of <i>Streptococcus suis</i> Isolated from Diseased Pigs in Thailand, 2018–2020 |
| title_short | Antimicrobial Susceptibility of <i>Streptococcus suis</i> Isolated from Diseased Pigs in Thailand, 2018–2020 |
| title_sort | antimicrobial susceptibility of i streptococcus suis i isolated from diseased pigs in thailand 2018 2020 |
| topic | antimicrobial resistance AMR multidrug resistance MDR surveillance zoonosis |
| url | https://www.mdpi.com/2079-6382/11/3/410 |
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