Cannabidiol Produces Distinct U-Shaped Dose-Response Effects on Cocaine-Induced Conditioned Place Preference and Associated Recruitment of Prelimbic Neurons in Male Rats

Cannabidiol Produces Distinct U-Shaped Dose-Response Effects on Cocaine-Induced Conditioned Place Preference and Associated Recruitment of Prelimbic Neurons in Male Rats

Background: Cannabidiol (CBD) has received attention for the treatment of substance use disorders. In preclinical models of relapse, CBD attenuates drug seeking across several drugs of abuse, including cocaine. However, in these models CBD has not been consistently effective. This inconsistency in C...

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Bibliographic Details
Main Authors: Hermina Nedelescu, Grant E. Wagner, Genna L. De Ness, Ayla Carroll, Tony M. Kerr, Jingjun Wang, Saiwen Zhang, Stephen Chang, Amy H. Than, Nora E. Emerson, Nobuyoshi Suto, Friedbert Weiss
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Biological Psychiatry Global Open Science
Subjects:
Cannabidiol
Cocaine
Conditioned place preference
Dose-response
U-Shape
RNAscope
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174321000604

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