Shengjiang Xiexin Decoction Alters Pharmacokinetics of Irinotecan by Regulating Metabolic Enzymes and Transporters: A Multi-Target Therapy for Alleviating the Gastrointestinal Toxicity

Shengjiang Xiexin Decoction Alters Pharmacokinetics of Irinotecan by Regulating Metabolic Enzymes and Transporters: A Multi-Target Therapy for Alleviating the Gastrointestinal Toxicity

Shengjiang Xiexin decoction (SXD), a classic traditional Chinese medical formula chronicled in Shang Han Lun, is used in modern clinical practice to decrease gastrointestinal toxicity induced by the chemotherapeutic drug irinotecan (CPT-11). In this study, the effect of SXD on the pharmacokinetics o...

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Bibliographic Details
Main Authors:	Huan-yu Guan, Peng-fei Li, Xiao-ming Wang, Jia-jing Yue, Yang He, Xiao-mei Luo, Mei-feng Su, Shang-gao Liao, Yue Shi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-10-01
Series:	Frontiers in Pharmacology
Subjects:	Shengjiang Xiexin decoction irinotecan (CPT-11) diarrhea pharmacokinetics UHPLC-MS/MS
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00769/full

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