Darier disease: the use of dermoscopy in monitoring acitretin treatment
Abstract Darier disease is an uncommon autosomal dominant inherited disease, caused by a mutation in the ATP2A2 gene. The clinical findings are hyperkeratotic papules on the trunk, scalp, face, and neck, maceration of intertriginous areas, palmar pits, whitish papules on the oral mucosa and nail abn...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2022-09-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500644&tlng=en |
| _version_ | 1817980592529080320 |
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| author | Catalina Silva-Hirschberg Raúl Cabrera María Paz Rollán Alex Castro |
| author_facet | Catalina Silva-Hirschberg Raúl Cabrera María Paz Rollán Alex Castro |
| author_sort | Catalina Silva-Hirschberg |
| collection | DOAJ |
| description | Abstract Darier disease is an uncommon autosomal dominant inherited disease, caused by a mutation in the ATP2A2 gene. The clinical findings are hyperkeratotic papules on the trunk, scalp, face, and neck, maceration of intertriginous areas, palmar pits, whitish papules on the oral mucosa and nail abnormalities. The main histopathologic findings are acantholysis and dyskeratotic keratinocytes. Dermatoscopic features are comedo-like openings with a central polygonal yellowish/brownish structure, surrounded by a whitish halo. First-line treatment includes acitretin. Five reports have been published describing Darier disease dermatoscopic findings. Herein, we report for the first time a patient under acitretin treatment and dermatoscopic follow-up. |
| first_indexed | 2024-04-13T22:55:24Z |
| format | Article |
| id | doaj.art-f01ffd110d2d4b06870e694c6ec7c639 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-13T22:55:24Z |
| publishDate | 2022-09-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-f01ffd110d2d4b06870e694c6ec7c6392022-12-22T02:26:02ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962022-09-0197564464710.1016/j.abd.2021.05.021Darier disease: the use of dermoscopy in monitoring acitretin treatmentCatalina Silva-Hirschberghttps://orcid.org/0000-0002-4276-1284Raúl Cabrerahttps://orcid.org/0000-0002-0180-9130María Paz Rollánhttps://orcid.org/0000-0003-0282-9288Alex Castrohttps://orcid.org/0000-0003-4431-5293Abstract Darier disease is an uncommon autosomal dominant inherited disease, caused by a mutation in the ATP2A2 gene. The clinical findings are hyperkeratotic papules on the trunk, scalp, face, and neck, maceration of intertriginous areas, palmar pits, whitish papules on the oral mucosa and nail abnormalities. The main histopathologic findings are acantholysis and dyskeratotic keratinocytes. Dermatoscopic features are comedo-like openings with a central polygonal yellowish/brownish structure, surrounded by a whitish halo. First-line treatment includes acitretin. Five reports have been published describing Darier disease dermatoscopic findings. Herein, we report for the first time a patient under acitretin treatment and dermatoscopic follow-up.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500644&tlng=enAcitretinDarier diseaseDermoscopyRetinoidsTherapy |
| spellingShingle | Catalina Silva-Hirschberg Raúl Cabrera María Paz Rollán Alex Castro Darier disease: the use of dermoscopy in monitoring acitretin treatment Anais Brasileiros de Dermatologia Acitretin Darier disease Dermoscopy Retinoids Therapy |
| title | Darier disease: the use of dermoscopy in monitoring acitretin treatment |
| title_full | Darier disease: the use of dermoscopy in monitoring acitretin treatment |
| title_fullStr | Darier disease: the use of dermoscopy in monitoring acitretin treatment |
| title_full_unstemmed | Darier disease: the use of dermoscopy in monitoring acitretin treatment |
| title_short | Darier disease: the use of dermoscopy in monitoring acitretin treatment |
| title_sort | darier disease the use of dermoscopy in monitoring acitretin treatment |
| topic | Acitretin Darier disease Dermoscopy Retinoids Therapy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500644&tlng=en |
| work_keys_str_mv | AT catalinasilvahirschberg darierdiseasetheuseofdermoscopyinmonitoringacitretintreatment AT raulcabrera darierdiseasetheuseofdermoscopyinmonitoringacitretintreatment AT mariapazrollan darierdiseasetheuseofdermoscopyinmonitoringacitretintreatment AT alexcastro darierdiseasetheuseofdermoscopyinmonitoringacitretintreatment |