Identification of the Tumor Immune Microenvironment and Therapeutic Biomarkers by a Novel Molecular Subtype Based on Aging-Related Genes in Hepatocellular Carcinoma

Identification of the Tumor Immune Microenvironment and Therapeutic Biomarkers by a Novel Molecular Subtype Based on Aging-Related Genes in Hepatocellular Carcinoma

BackgroundHepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors with poor prognosis. Increasing evidence has revealed that immune cells and checkpoints in the tumor microenvironment (TME) and aging are associated with the prognosis of HCC. However, the association between agin...

Full description

Bibliographic Details
Main Authors:	Dong Cai, Zhibo Zhao, Jiejun Hu, Xin Dai, Guochao Zhong, Jianping Gong, Feng Qi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Surgery
Subjects:	hepatocellular carcinoma (HCC) immune cells immune checkpoints tumor immune microenvironment (TIME) aging therapeutic biomarkers
Online Access:	https://www.frontiersin.org/articles/10.3389/fsurg.2022.836080/full

Similar Items

Identification of a Prognostic Model Based on 2-Gene Signature and Analysis of Corresponding Tumor Microenvironment in Alcohol-Related Hepatocellular Carcinoma
by: Yong Guo, et al.
Published: (2021-09-01)

Copper and cuproptosis-related genes in hepatocellular carcinoma: therapeutic biomarkers targeting tumor immune microenvironment and immune checkpoints
by: Xiaoqiang Wang, et al.
Published: (2023-04-01)

Angiogenesis-Related Immune Signatures Correlate With Prognosis, Tumor Microenvironment, and Therapeutic Sensitivity in Hepatocellular Carcinoma
by: Yuan Yang, et al.
Published: (2021-06-01)

Emerging Role of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
by: Vito Longo, et al.
Published: (2019-10-01)

Biomarkers predicting the efficacy of immune checkpoint inhibitors in hepatocellular carcinoma
by: Ran Qin, et al.
Published: (2023-12-01)

The Evolving Role of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma Treatment
by: Patrizia Leone, et al.
Published: (2021-05-01)

The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma
by: Bufu Tang, et al.
Published: (2020-10-01)

CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment
by: Yinjiang Zhang, et al.
Published: (2021-08-01)

Identification of Two Distinct Immune Subtypes in Hepatitis B Virus (HBV)-Associated Hepatocellular Carcinoma (HCC)
by: Davide De Battista, et al.
Published: (2024-03-01)

Potential therapeutic targets in the tumor microenvironment of hepatocellular carcinoma: reversing the protumor effect of tumor-associated macrophages
by: Jingyi Zhou, et al.
Published: (2021-02-01)

A pyroptosis-related gene signature predicts prognosis and immune microenvironment in hepatocellular carcinoma
by: Yifeng Jin, et al.
Published: (2022-06-01)

Novel Perspectives in Immune Checkpoint Inhibitors and the Management of Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma
by: Landon L. Chan, et al.
Published: (2022-03-01)

Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment
by: Mariam Mroweh, et al.
Published: (2021-02-01)

Immune checkpoint inhibitors in the treatment of hepatocellular carcinoma
by: Zeynep Akbulut, et al.
Published: (2024-04-01)

Predictive Biomarkers for Immune-Checkpoint Inhibitor Treatment Response in Patients with Hepatocellular Carcinoma
by: Jun Ho Ji, et al.
Published: (2023-04-01)

The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?
by: Jiayao Ma, et al.
Published: (2021-10-01)

Favorable outcome of immunotherapy in a rare subtype of hepatocellular carcinoma: a case report and literature review
by: Anita Archwamety, et al.
Published: (2024-04-01)

Identification of lipid metabolism-associated genes as prognostic biomarkers based on the immune microenvironment in hepatocellular carcinoma
by: Xiangqian Gu, et al.
Published: (2022-10-01)

A novel immune checkpoint-related gene signature for hepatocellular carcinoma to predict clinical outcomes and therapeutic response
by: Siyuan Tian, et al.
Published: (2022-03-01)

Biomarkers and Future Perspectives for Hepatocellular Carcinoma Immunotherapy
by: Yuqing He, et al.
Published: (2021-09-01)

CENPO is Associated with Immune Cell Infiltration and is a Potential Diagnostic and Prognostic Marker for Hepatocellular Carcinoma
by: He K, et al.
Published: (2022-09-01)

OX40 expression in hepatocellular carcinoma is associated with a distinct immune microenvironment, specific mutation signature, and poor prognosis
by: Kunlin Xie, et al.
Published: (2018-04-01)

NIFK, an independent prognostic biomarker of hepatocellular carcinoma, is correlated with immune infiltration
by: Fei Cheng, et al.
Published: (2023-05-01)

Serine Protease Inhibitor Kazal Type 1, A Potential Biomarker for the Early Detection, Targeting, and Prediction of Response to Immune Checkpoint Blockade Therapies in Hepatocellular Carcinoma
by: Jianlong Jia, et al.
Published: (2022-07-01)

Crosstalk Between the Tumor Microenvironment and Cancer Cells: A Promising Predictive Biomarker for Immune Checkpoint Inhibitors
by: Xiaoying Li, et al.
Published: (2021-10-01)

Pan‐cancer analysis identifies TERT alterations as predictive biomarkers for immune checkpoint inhibitors treatment
by: Tao Jiang, et al.
Published: (2020-06-01)

MUTYH is a potential prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma
by: Fan Yang, et al.
Published: (2022-12-01)

Role of β-Catenin Activation in the Tumor Immune Microenvironment and Immunotherapy of Hepatocellular Carcinoma
by: Masahiro Morita, et al.
Published: (2023-04-01)

Characterization of immune features and immunotherapy response in subtypes of hepatocellular carcinoma based on mitophagy
by: Yanan Wang, et al.
Published: (2022-10-01)

Overexpression of SMS in the tumor microenvironment is associated with immunosuppression in hepatocellular carcinoma
by: Lin Xiang, et al.
Published: (2022-12-01)

Advanced development of biomarkers for immunotherapy in hepatocellular carcinoma
by: Xuenan Peng, et al.
Published: (2023-01-01)

How Immunotherapy Has Changed the Continuum of Care in Hepatocellular Carcinoma
by: Giulia Martini, et al.
Published: (2021-09-01)

Exosomes as mediators of tumor immune escape and immunotherapy in hepatocellular carcinoma
by: Ming-Cheng Guan, et al.
Published: (2022-09-01)

Role of 5-methylcytosine in determining the prognosis, tumor microenvironment, and applicability of precision medicine in patients with hepatocellular carcinoma
by: Mingyuan Luan, et al.
Published: (2022-09-01)

Fibroblast growth factor receptor family mutations as a predictive biomarker for immune checkpoint inhibitors and its correlation with tumor immune microenvironment in melanoma
by: Wengang Zhang, et al.
Published: (2022-11-01)

Identification of a prognostic and therapeutic immune signature associated with hepatocellular carcinoma
by: Yanan Peng, et al.
Published: (2021-02-01)

Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention
by: Li Zhuang, et al.
Published: (2024-01-01)

KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity
by: Rui Fan, et al.
Published: (2024-04-01)

Predictive Models for HCC Prognosis, Recurrence Risk, and Immune Infiltration Based on Two Exosomal Genes: MYL6B and THOC2
by: Zhu J, et al.
Published: (2021-08-01)

Biomarkers of Response and Resistance to Immunotherapy in Microsatellite Stable Colorectal Cancer: Toward a New Personalized Medicine
by: Nicolas Huyghe, et al.
Published: (2022-04-01)