Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical Study
Background and aims. The aim of this clinical investigation was to compare clinical and microbiological effectiveness of adjunctive CHX gel in the treatment of periodontitis. Materials and methods. Twenty-four subjects with localized or generalized moderate-to-severe chronic periodontitis underwe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2013-06-01
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| Series: | Journal of Dental Research, Dental Clinics, Dental Prospects |
| Subjects: | |
| Online Access: | http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/463/295 |
| _version_ | 1811205197098123264 |
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| author | Mohammad Taghi Chitsazi Atabak Kashefimehr Reza Pourabbas Adileh Shirmohammadi Vadood Ghasemi Barghi Behrouz Daghigh Azar |
| author_facet | Mohammad Taghi Chitsazi Atabak Kashefimehr Reza Pourabbas Adileh Shirmohammadi Vadood Ghasemi Barghi Behrouz Daghigh Azar |
| author_sort | Mohammad Taghi Chitsazi |
| collection | DOAJ |
| description | Background and aims. The aim of this clinical investigation was to compare clinical and microbiological effectiveness
of adjunctive CHX gel in the treatment of periodontitis.
Materials and methods. Twenty-four subjects with localized or generalized moderate-to-severe chronic periodontitis
underwent scaling and root planing. One tooth in each quadrant with a probing depth of >4 mm was chosen for combined
gel and SRP, with contralateral tooth as control (SRP treated site). Clinical assessment was carried out at baseline and 1 and
3 months later; microbial assessment was performed by real-time PCR. Periodontal probing depth (PPD) was considered as
primary outcome.
Results. Twenty patients completed the study. Baseline PPDs were 4.90±0.78 and 5.05±0.79 in the SRP and gel groups,
respectively (P>0.05), which decreased to 3.67±0.59 and 3.7±0.83 one month after treatment and 3.25±0.65 and 3.38±0.79
three months after treatment. Although values decreased significantly in both groups after one and three months (P=0.001 in
the SRP and P=0.001 in the gel group), the inter-group difference was not significant neither at one-month (P=0.47) nor at
three-month (P=0.77) intervals. The only clinical parameters exhibiting statistically significant inter-group differences was
BOP in both one-month (P=0.004) and three-month (P=0.0001) intervals. All the other clinical measurements showed significant
decreases after one and three months in both sites but without inter-group differences.
Conclusion. Subgingival application of xanthan chlorhexidine gel combined with scaling and root planing reduced bleeding
of periodontal pockets. Clinical trials to evaluate effectiveness of this gel in aggressive and severe periodontitis modified
by systemic factors are suggested |
| first_indexed | 2024-04-12T03:26:40Z |
| format | Article |
| id | doaj.art-f021ef13adf9407bb2dfdbb19e9ac0e8 |
| institution | Directory Open Access Journal |
| issn | 2008-210X 2008-2118 |
| language | English |
| last_indexed | 2024-04-12T03:26:40Z |
| publishDate | 2013-06-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Dental Research, Dental Clinics, Dental Prospects |
| spelling | doaj.art-f021ef13adf9407bb2dfdbb19e9ac0e82022-12-22T03:49:41ZengTabriz University of Medical SciencesJournal of Dental Research, Dental Clinics, Dental Prospects2008-210X2008-21182013-06-01729510110.5681/joddd.2013.017Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical StudyMohammad Taghi Chitsazi0Atabak Kashefimehr1Reza Pourabbas2Adileh Shirmohammadi3Vadood Ghasemi Barghi4Behrouz Daghigh Azar5Associate Professor, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Assistant Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, IranProfessor, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, IranAssociate Professor, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Post-graduate Student, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Master of Science, Head of DANESH Molecular Pathology LaboratoryBackground and aims. The aim of this clinical investigation was to compare clinical and microbiological effectiveness of adjunctive CHX gel in the treatment of periodontitis. Materials and methods. Twenty-four subjects with localized or generalized moderate-to-severe chronic periodontitis underwent scaling and root planing. One tooth in each quadrant with a probing depth of >4 mm was chosen for combined gel and SRP, with contralateral tooth as control (SRP treated site). Clinical assessment was carried out at baseline and 1 and 3 months later; microbial assessment was performed by real-time PCR. Periodontal probing depth (PPD) was considered as primary outcome. Results. Twenty patients completed the study. Baseline PPDs were 4.90±0.78 and 5.05±0.79 in the SRP and gel groups, respectively (P>0.05), which decreased to 3.67±0.59 and 3.7±0.83 one month after treatment and 3.25±0.65 and 3.38±0.79 three months after treatment. Although values decreased significantly in both groups after one and three months (P=0.001 in the SRP and P=0.001 in the gel group), the inter-group difference was not significant neither at one-month (P=0.47) nor at three-month (P=0.77) intervals. The only clinical parameters exhibiting statistically significant inter-group differences was BOP in both one-month (P=0.004) and three-month (P=0.0001) intervals. All the other clinical measurements showed significant decreases after one and three months in both sites but without inter-group differences. Conclusion. Subgingival application of xanthan chlorhexidine gel combined with scaling and root planing reduced bleeding of periodontal pockets. Clinical trials to evaluate effectiveness of this gel in aggressive and severe periodontitis modified by systemic factors are suggestedhttp://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/463/295Xanthan-based chlorhexidine gelreal-time PCRperiodontitis |
| spellingShingle | Mohammad Taghi Chitsazi Atabak Kashefimehr Reza Pourabbas Adileh Shirmohammadi Vadood Ghasemi Barghi Behrouz Daghigh Azar Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical Study Journal of Dental Research, Dental Clinics, Dental Prospects Xanthan-based chlorhexidine gel real-time PCR periodontitis |
| title | Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical Study |
| title_full | Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical Study |
| title_fullStr | Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical Study |
| title_full_unstemmed | Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical Study |
| title_short | Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical Study |
| title_sort | efficacy of subgingival application of xanthan based chlorhexidine gel adjunctive to full mouth root planing assessed by real time pcr a microbiologic and clinical study |
| topic | Xanthan-based chlorhexidine gel real-time PCR periodontitis |
| url | http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/463/295 |
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