The Biological and Molecular Function of LINC00665 in Human Cancers
Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and are implicated in the development of human cancers, without protein-coding function. Mounting evidence indicates that cancer initiation and progression are triggered by lncRNA dysregulation. Recently, a growing number of stud...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.886034/full |
| _version_ | 1818210846202920960 |
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| author | Cheng Zhang Shu-Ning Xu Ke Li Jing-Hong Chen Qun Li Ying Liu |
| author_facet | Cheng Zhang Shu-Ning Xu Ke Li Jing-Hong Chen Qun Li Ying Liu |
| author_sort | Cheng Zhang |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and are implicated in the development of human cancers, without protein-coding function. Mounting evidence indicates that cancer initiation and progression are triggered by lncRNA dysregulation. Recently, a growing number of studies have found that LINC00665, a long intergenic non-protein coding RNA, may be associated with various cancers, including gastrointestinal tumors, gynecological tumors, and respiratory neoplasms. LINC00665 was reported to be significantly dysregulated in cancers and has an important clinical association. It participates in cell proliferation, migration, invasion, and apoptosis through different biological pathways. In this review, we summarize the current findings on LINC00665, including its biological roles and molecular mechanisms in various cancers. LINC00665 may be a potential prognostic biomarker and novel therapeutic target for cancers. |
| first_indexed | 2024-12-12T05:23:05Z |
| format | Article |
| id | doaj.art-f021f73dcf584d1fa5d4d1adac7adf96 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T05:23:05Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f021f73dcf584d1fa5d4d1adac7adf962022-12-22T00:36:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.886034886034The Biological and Molecular Function of LINC00665 in Human CancersCheng ZhangShu-Ning XuKe LiJing-Hong ChenQun LiYing LiuLong non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and are implicated in the development of human cancers, without protein-coding function. Mounting evidence indicates that cancer initiation and progression are triggered by lncRNA dysregulation. Recently, a growing number of studies have found that LINC00665, a long intergenic non-protein coding RNA, may be associated with various cancers, including gastrointestinal tumors, gynecological tumors, and respiratory neoplasms. LINC00665 was reported to be significantly dysregulated in cancers and has an important clinical association. It participates in cell proliferation, migration, invasion, and apoptosis through different biological pathways. In this review, we summarize the current findings on LINC00665, including its biological roles and molecular mechanisms in various cancers. LINC00665 may be a potential prognostic biomarker and novel therapeutic target for cancers.https://www.frontiersin.org/articles/10.3389/fonc.2022.886034/fullcancerlncRNALINC00665biological rolesbiomarker |
| spellingShingle | Cheng Zhang Shu-Ning Xu Ke Li Jing-Hong Chen Qun Li Ying Liu The Biological and Molecular Function of LINC00665 in Human Cancers Frontiers in Oncology cancer lncRNA LINC00665 biological roles biomarker |
| title | The Biological and Molecular Function of LINC00665 in Human Cancers |
| title_full | The Biological and Molecular Function of LINC00665 in Human Cancers |
| title_fullStr | The Biological and Molecular Function of LINC00665 in Human Cancers |
| title_full_unstemmed | The Biological and Molecular Function of LINC00665 in Human Cancers |
| title_short | The Biological and Molecular Function of LINC00665 in Human Cancers |
| title_sort | biological and molecular function of linc00665 in human cancers |
| topic | cancer lncRNA LINC00665 biological roles biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.886034/full |
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