Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia
Background: While in symptomatic forms of dystonia cerebral pathology is by definition present, it is unclear so far whether disease is associated with microstructural cerebral changes in idiopathic dystonia. Previous quantitative MRI (qMRI) studies assessing cerebral tissue composition in idiopathi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00914/full |
| _version_ | 1818620708696096768 |
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| author | René-Maxime Gracien René-Maxime Gracien Franca Petrov Franca Petrov Pavel Hok Pavel Hok Alexandra van Wijnen Alexandra van Wijnen Michelle Maiworm Michelle Maiworm Alexander Seiler Alexander Seiler Ralf Deichmann Simon Baudrexel Simon Baudrexel |
| author_facet | René-Maxime Gracien René-Maxime Gracien Franca Petrov Franca Petrov Pavel Hok Pavel Hok Alexandra van Wijnen Alexandra van Wijnen Michelle Maiworm Michelle Maiworm Alexander Seiler Alexander Seiler Ralf Deichmann Simon Baudrexel Simon Baudrexel |
| author_sort | René-Maxime Gracien |
| collection | DOAJ |
| description | Background: While in symptomatic forms of dystonia cerebral pathology is by definition present, it is unclear so far whether disease is associated with microstructural cerebral changes in idiopathic dystonia. Previous quantitative MRI (qMRI) studies assessing cerebral tissue composition in idiopathic dystonia revealed conflicting results.Objective: Using multimodal qMRI, the presented study aimed to investigate alterations in different cerebral microstructural compartments associated with idiopathic cervical dystonia in vivo.Methods: Mapping of T1, T2, T2*, and proton density (PD) was performed in 17 patients with idiopathic cervical dystonia and 29 matched healthy control subjects. Statistical comparisons of the parametric maps between groups were conducted for various regions of interest (ROI), including major basal ganglia nuclei, the thalamus, white matter, and the cerebellum, and voxel-wise for the whole brain.Results: Neither whole brain voxel-wise statistics nor ROI-based analyses revealed significant group differences for any qMRI parameter under investigation.Conclusions: The negative findings of this qMRI study argue against the presence of overt microstructural tissue change in patients with idiopathic cervical dystonia. The results seem to support a common view that idiopathic cervical dystonia might primarily resemble a functional network disease. |
| first_indexed | 2024-12-16T17:57:41Z |
| format | Article |
| id | doaj.art-f025c139d436410f9411a9bbdf550d27 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T17:57:41Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f025c139d436410f9411a9bbdf550d272022-12-21T22:22:08ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-08-011010.3389/fneur.2019.00914468899Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical DystoniaRené-Maxime Gracien0René-Maxime Gracien1Franca Petrov2Franca Petrov3Pavel Hok4Pavel Hok5Alexandra van Wijnen6Alexandra van Wijnen7Michelle Maiworm8Michelle Maiworm9Alexander Seiler10Alexander Seiler11Ralf Deichmann12Simon Baudrexel13Simon Baudrexel14Department of Neurology, Goethe University, Frankfurt, GermanyBrain Imaging Center, Goethe University, Frankfurt, GermanyDepartment of Neurology, Goethe University, Frankfurt, GermanyBrain Imaging Center, Goethe University, Frankfurt, GermanyDepartment of Neurology, Goethe University, Frankfurt, GermanyDepartment of Neurology, Palacký University Olomouc and University Hospital Olomouc, Olomouc, CzechiaDepartment of Neurology, Goethe University, Frankfurt, GermanyBrain Imaging Center, Goethe University, Frankfurt, GermanyDepartment of Neurology, Goethe University, Frankfurt, GermanyBrain Imaging Center, Goethe University, Frankfurt, GermanyDepartment of Neurology, Goethe University, Frankfurt, GermanyBrain Imaging Center, Goethe University, Frankfurt, GermanyBrain Imaging Center, Goethe University, Frankfurt, GermanyDepartment of Neurology, Goethe University, Frankfurt, GermanyBrain Imaging Center, Goethe University, Frankfurt, GermanyBackground: While in symptomatic forms of dystonia cerebral pathology is by definition present, it is unclear so far whether disease is associated with microstructural cerebral changes in idiopathic dystonia. Previous quantitative MRI (qMRI) studies assessing cerebral tissue composition in idiopathic dystonia revealed conflicting results.Objective: Using multimodal qMRI, the presented study aimed to investigate alterations in different cerebral microstructural compartments associated with idiopathic cervical dystonia in vivo.Methods: Mapping of T1, T2, T2*, and proton density (PD) was performed in 17 patients with idiopathic cervical dystonia and 29 matched healthy control subjects. Statistical comparisons of the parametric maps between groups were conducted for various regions of interest (ROI), including major basal ganglia nuclei, the thalamus, white matter, and the cerebellum, and voxel-wise for the whole brain.Results: Neither whole brain voxel-wise statistics nor ROI-based analyses revealed significant group differences for any qMRI parameter under investigation.Conclusions: The negative findings of this qMRI study argue against the presence of overt microstructural tissue change in patients with idiopathic cervical dystonia. The results seem to support a common view that idiopathic cervical dystonia might primarily resemble a functional network disease.https://www.frontiersin.org/article/10.3389/fneur.2019.00914/fullidiopathic dystoniaquantitative MRIrelaxometryproton densitymovement disorders |
| spellingShingle | René-Maxime Gracien René-Maxime Gracien Franca Petrov Franca Petrov Pavel Hok Pavel Hok Alexandra van Wijnen Alexandra van Wijnen Michelle Maiworm Michelle Maiworm Alexander Seiler Alexander Seiler Ralf Deichmann Simon Baudrexel Simon Baudrexel Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia Frontiers in Neurology idiopathic dystonia quantitative MRI relaxometry proton density movement disorders |
| title | Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia |
| title_full | Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia |
| title_fullStr | Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia |
| title_full_unstemmed | Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia |
| title_short | Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia |
| title_sort | multimodal quantitative mri reveals no evidence for tissue pathology in idiopathic cervical dystonia |
| topic | idiopathic dystonia quantitative MRI relaxometry proton density movement disorders |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00914/full |
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