3,3′,4,5′-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress

3,3′,4,5′-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress

The potential anti-diabetic effect of resveratrol derivative, 3,3′,4,5′-tetramethoxy-trans-stilbene (3,3′,4,5′-TMS) and its underlying mechanism in high glucose (HG) and dexamethasone (DXMS)-stimulated insulin-resistant HepG2 cells (IR-HepG2) were investigated. 3,3′,4,5′-TMS did not reduce the cell...

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Bibliographic Details
Main Authors: Yi Tan, Lingchao Miao, Jianbo Xiao, Wai San Cheang
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Current Issues in Molecular Biology
Subjects:
3,3′,4,5′-tetramethoxy-trans-stilbene
HepG2 cells
insulin resistance
oxidative stress
glucose consumption
glycogen synthesis
Online Access:https://www.mdpi.com/1467-3045/44/5/147

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