Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study
Abstract Background Previous studies have shown that osteoarthritis (OA) and sarcopenia (SP) are closely related to each other, but the causal relationships between them have not been established. The aim of this study was to investigate the causal associations between OA and SP via a bi-directional...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01322-0 |
| _version_ | 1797577342545035264 |
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| author | Jiyong Yang Peng Liu Shuai Wang Tao Jiang Yilong Zhang Wengang Liu |
| author_facet | Jiyong Yang Peng Liu Shuai Wang Tao Jiang Yilong Zhang Wengang Liu |
| author_sort | Jiyong Yang |
| collection | DOAJ |
| description | Abstract Background Previous studies have shown that osteoarthritis (OA) and sarcopenia (SP) are closely related to each other, but the causal relationships between them have not been established. The aim of this study was to investigate the causal associations between OA and SP via a bi-directional Mendelian randomization (MR) approach. Methods A bi-directional two-sample MR was adopted to research the causal relationship between SP and OA. The instrumental variables for SP and four types of OA: KOA, HOA, total knee replacement (TKR) and total hip replacement (THR) were derived from published large genome-wide association studies (GWAS). The inverse variance weighted (IVW), MR-Egger and weighted median estimator (WME) methods were used to estimate bi-directional causal effects. Results Low grip strength (GS) did not have a causal effect on four types of OA (KOA: OR = 1.205, 95% CI 0.837–1.734, p = 0.316; HOA: OR = 1.090, 95% CI 0.924–1.609, p = 0.307; TKR: OR = 1.190, 95% CI 1.084–1.307, p = 0.058; THR: OR = 1.035, 95% CI 0.792–1.353, p = 0.798), while appendicular lean mass (ALM) had a causal effect on four types of OA (KOA: OR = 1.104, 95% CI 1.041–1.171, p = 0.001; HOA: OR = 1.151, 95% CI 1.071–1.237, p < 0.001; TKR: OR = 1.114, 95% CI 1.007–1.232, p < 0.001; THR: OR = 1.203, 95% CI 1.099–1.316, p < 0.001). In the reverse direction, KOA or HOA did not have a significant causal effect on both GS and ALM (KOA-GS: OR = 1.077, 95% CI 0.886–1.309, p = 0.458; KOA-ALM: Beta = 0.004, p = 0.892; HOA-GS: OR = 1.038, 95% CI 0.981–1.099, p = 0.209; HOA-ALM: Beta = − 0.017, p = 0.196; TKR-GS: OR = 0.999, 95% CI 0.739–1.351, p = 0.997; TKR-ALM: Beta = 0.018, p = 0.501; THR-GS: OR = 1.037, 95% CI 0.978–1.101, p = 0.222; THR-ALM: Beta = − 0.023, p = 0.081). Conclusions The present study suggests that SP may have a causal effect on OA through changes in muscle composition rather than muscle strength, while little evidence was provided for the causal effect of OA on SP. |
| first_indexed | 2024-03-10T22:06:53Z |
| format | Article |
| id | doaj.art-f027b774d8504a46ad089ad98af3bc5a |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-10T22:06:53Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-f027b774d8504a46ad089ad98af3bc5a2023-11-19T12:46:42ZengBMCEuropean Journal of Medical Research2047-783X2023-09-012811910.1186/s40001-023-01322-0Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized studyJiyong Yang0Peng Liu1Shuai Wang2Tao Jiang3Yilong Zhang4Wengang Liu5The Fifth Clinical College of Guangzhou, University of Chinese MedicineThe First Affiliated Hospital of Sun Yat-sen UniversityThe Fifth Clinical College of Guangzhou, University of Chinese MedicineDepartment of Orthopedics, Guangdong Second Traditional Chinese Medicine HospitalThe Fifth Clinical College of Guangzhou, University of Chinese MedicineDepartment of Orthopedics, Guangdong Second Traditional Chinese Medicine HospitalAbstract Background Previous studies have shown that osteoarthritis (OA) and sarcopenia (SP) are closely related to each other, but the causal relationships between them have not been established. The aim of this study was to investigate the causal associations between OA and SP via a bi-directional Mendelian randomization (MR) approach. Methods A bi-directional two-sample MR was adopted to research the causal relationship between SP and OA. The instrumental variables for SP and four types of OA: KOA, HOA, total knee replacement (TKR) and total hip replacement (THR) were derived from published large genome-wide association studies (GWAS). The inverse variance weighted (IVW), MR-Egger and weighted median estimator (WME) methods were used to estimate bi-directional causal effects. Results Low grip strength (GS) did not have a causal effect on four types of OA (KOA: OR = 1.205, 95% CI 0.837–1.734, p = 0.316; HOA: OR = 1.090, 95% CI 0.924–1.609, p = 0.307; TKR: OR = 1.190, 95% CI 1.084–1.307, p = 0.058; THR: OR = 1.035, 95% CI 0.792–1.353, p = 0.798), while appendicular lean mass (ALM) had a causal effect on four types of OA (KOA: OR = 1.104, 95% CI 1.041–1.171, p = 0.001; HOA: OR = 1.151, 95% CI 1.071–1.237, p < 0.001; TKR: OR = 1.114, 95% CI 1.007–1.232, p < 0.001; THR: OR = 1.203, 95% CI 1.099–1.316, p < 0.001). In the reverse direction, KOA or HOA did not have a significant causal effect on both GS and ALM (KOA-GS: OR = 1.077, 95% CI 0.886–1.309, p = 0.458; KOA-ALM: Beta = 0.004, p = 0.892; HOA-GS: OR = 1.038, 95% CI 0.981–1.099, p = 0.209; HOA-ALM: Beta = − 0.017, p = 0.196; TKR-GS: OR = 0.999, 95% CI 0.739–1.351, p = 0.997; TKR-ALM: Beta = 0.018, p = 0.501; THR-GS: OR = 1.037, 95% CI 0.978–1.101, p = 0.222; THR-ALM: Beta = − 0.023, p = 0.081). Conclusions The present study suggests that SP may have a causal effect on OA through changes in muscle composition rather than muscle strength, while little evidence was provided for the causal effect of OA on SP.https://doi.org/10.1186/s40001-023-01322-0OsteoarthritisSarcopeniaSarcopenic osteoarthritisMendelian randomizationCausal relationship |
| spellingShingle | Jiyong Yang Peng Liu Shuai Wang Tao Jiang Yilong Zhang Wengang Liu Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study European Journal of Medical Research Osteoarthritis Sarcopenia Sarcopenic osteoarthritis Mendelian randomization Causal relationship |
| title | Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study |
| title_full | Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study |
| title_fullStr | Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study |
| title_full_unstemmed | Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study |
| title_short | Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study |
| title_sort | causal relationship between sarcopenia and osteoarthritis a bi directional two sample mendelian randomized study |
| topic | Osteoarthritis Sarcopenia Sarcopenic osteoarthritis Mendelian randomization Causal relationship |
| url | https://doi.org/10.1186/s40001-023-01322-0 |
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