Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy
Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogene...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/3/879 |
| _version_ | 1797609535634931712 |
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| author | Yedi Herdiana Nasrul Wathoni Dolih Gozali Shaharum Shamsuddin Muchtaridi Muchtaridi |
| author_facet | Yedi Herdiana Nasrul Wathoni Dolih Gozali Shaharum Shamsuddin Muchtaridi Muchtaridi |
| author_sort | Yedi Herdiana |
| collection | DOAJ |
| description | Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results. |
| first_indexed | 2024-03-11T06:02:46Z |
| format | Article |
| id | doaj.art-f0284ed3f18b4208bcb047d438be5a21 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T06:02:46Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f0284ed3f18b4208bcb047d438be5a212023-11-17T13:15:41ZengMDPI AGPharmaceutics1999-49232023-03-0115387910.3390/pharmaceutics15030879Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer TherapyYedi Herdiana0Nasrul Wathoni1Dolih Gozali2Shaharum Shamsuddin3Muchtaridi Muchtaridi4Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDespite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results.https://www.mdpi.com/1999-4923/15/3/879nanocarriermultimodal deliverystimulus responsetargeting |
| spellingShingle | Yedi Herdiana Nasrul Wathoni Dolih Gozali Shaharum Shamsuddin Muchtaridi Muchtaridi Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy Pharmaceutics nanocarrier multimodal delivery stimulus response targeting |
| title | Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy |
| title_full | Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy |
| title_fullStr | Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy |
| title_full_unstemmed | Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy |
| title_short | Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy |
| title_sort | chitosan based nano smart drug delivery system in breast cancer therapy |
| topic | nanocarrier multimodal delivery stimulus response targeting |
| url | https://www.mdpi.com/1999-4923/15/3/879 |
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