Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern China
There is limited evidence linking antibiotic exposure, particularly from contaminated food or drinking water, to childhood obesity. The study aimed to investigate the association between urinary antibiotic levels and overweight/obesity in preschool children. In the case-control study, 121 overweight...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132301237X |
| _version_ | 1797448771021307904 |
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| author | Juan Wen Xiaodie Yao Shijie Geng Lijun Zhu Hua Jiang Lingmin Hu |
| author_facet | Juan Wen Xiaodie Yao Shijie Geng Lijun Zhu Hua Jiang Lingmin Hu |
| author_sort | Juan Wen |
| collection | DOAJ |
| description | There is limited evidence linking antibiotic exposure, particularly from contaminated food or drinking water, to childhood obesity. The study aimed to investigate the association between urinary antibiotic levels and overweight/obesity in preschool children. In the case-control study, 121 overweight/obese preschoolers and 242 controls (aged 3–6 years) from eastern China were enrolled in 2022 based on age, sex, and study site matching. Overweight/obesity was determined using body mass index (BMI) and weight for height (WFH) criteria derived from national data. A total of 50 antibiotics from 8 categories were analyzed using ultra-performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). We identified major dietary patterns using principal component analysis (PCA) and examined the associations of antibiotic exposure with childhood overweight/obesity using multivariate logistic regression. Twenty-four individual antibiotics were detected in more than 10 % of the samples, and overall detection rates were up to 100 %. Overweight/obese children had a higher exposure to veterinary antibiotics (VAs) than normal weight children. PCA analysis showed that children who were overweight/obese had higher scores of “Aquatic products preferred dietary pattern” and “Cereals preferred dietary pattern” compared to children with normal weight. Multivariate logistic regression analyses indicated that exposure to elevated levels of deoxytetracycline (OR: 1.72; 95 %CI: 1.00–2.93) and quinolones (OR: 1.63; 95 %CI: 1.04–2.57) was significantly related to an increased risk of BMI-based overweight/obesity. Quinolones exposure was also significantly associated with WFH-based overweight/obesity, primarily in boys. After adjustment for all covariates, higher exposure to ofloxacin (of the quinolones) was significantly related to overweight/obesity in girls. Exposure to certain antibiotics, especially quinolones, may increase the risk of overweight/obesity in preschoolers. More prospective, well-designed studies are needed to clarify these findings. |
| first_indexed | 2024-03-09T14:16:13Z |
| format | Article |
| id | doaj.art-f02902851d0940e3a72191561716173e |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-09T14:16:13Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-f02902851d0940e3a72191561716173e2023-11-29T04:23:42ZengElsevierEcotoxicology and Environmental Safety0147-65132024-01-01269115733Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern ChinaJuan Wen0Xiaodie Yao1Shijie Geng2Lijun Zhu3Hua Jiang4Lingmin Hu5Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210000, PR ChinaNanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210000, PR ChinaNanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210000, PR ChinaNanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210000, PR ChinaNanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210000, PR China; Corresponding authors.Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu 213000, PR China; Corresponding authors.There is limited evidence linking antibiotic exposure, particularly from contaminated food or drinking water, to childhood obesity. The study aimed to investigate the association between urinary antibiotic levels and overweight/obesity in preschool children. In the case-control study, 121 overweight/obese preschoolers and 242 controls (aged 3–6 years) from eastern China were enrolled in 2022 based on age, sex, and study site matching. Overweight/obesity was determined using body mass index (BMI) and weight for height (WFH) criteria derived from national data. A total of 50 antibiotics from 8 categories were analyzed using ultra-performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). We identified major dietary patterns using principal component analysis (PCA) and examined the associations of antibiotic exposure with childhood overweight/obesity using multivariate logistic regression. Twenty-four individual antibiotics were detected in more than 10 % of the samples, and overall detection rates were up to 100 %. Overweight/obese children had a higher exposure to veterinary antibiotics (VAs) than normal weight children. PCA analysis showed that children who were overweight/obese had higher scores of “Aquatic products preferred dietary pattern” and “Cereals preferred dietary pattern” compared to children with normal weight. Multivariate logistic regression analyses indicated that exposure to elevated levels of deoxytetracycline (OR: 1.72; 95 %CI: 1.00–2.93) and quinolones (OR: 1.63; 95 %CI: 1.04–2.57) was significantly related to an increased risk of BMI-based overweight/obesity. Quinolones exposure was also significantly associated with WFH-based overweight/obesity, primarily in boys. After adjustment for all covariates, higher exposure to ofloxacin (of the quinolones) was significantly related to overweight/obesity in girls. Exposure to certain antibiotics, especially quinolones, may increase the risk of overweight/obesity in preschoolers. More prospective, well-designed studies are needed to clarify these findings.http://www.sciencedirect.com/science/article/pii/S014765132301237XAntibioticsOverweightObesityPreschoolersEastern China |
| spellingShingle | Juan Wen Xiaodie Yao Shijie Geng Lijun Zhu Hua Jiang Lingmin Hu Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern China Ecotoxicology and Environmental Safety Antibiotics Overweight Obesity Preschoolers Eastern China |
| title | Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern China |
| title_full | Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern China |
| title_fullStr | Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern China |
| title_full_unstemmed | Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern China |
| title_short | Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern China |
| title_sort | urinary antibiotic levels and risk of overweight obesity in preschool children a biomonitoring based study from eastern china |
| topic | Antibiotics Overweight Obesity Preschoolers Eastern China |
| url | http://www.sciencedirect.com/science/article/pii/S014765132301237X |
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