Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins
Nearly all of biology depends on interactions between molecules: proteins with small molecules, proteins with other proteins, nucleic acids with small molecules, and nucleic acids with proteins that regulate gene expression, our concern in this Special Issue. All those kinds of interactions, and oth...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/1/562 |
| _version_ | 1797498707652902912 |
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| author | Jannette Carey |
| author_facet | Jannette Carey |
| author_sort | Jannette Carey |
| collection | DOAJ |
| description | Nearly all of biology depends on interactions between molecules: proteins with small molecules, proteins with other proteins, nucleic acids with small molecules, and nucleic acids with proteins that regulate gene expression, our concern in this Special Issue. All those kinds of interactions, and others, constitute the vast majority of biology at the molecular level. An understanding of those interactions requires that we quantify them to learn how they interact: How strongly? With which partners? How—and how well—are different partners distinguished? This review addresses the evolution of our current understanding of the molecular origins of affinity and specificity in regulatory protein–DNA interactions, and suggests that both these properties can be modulated by cooperativity. |
| first_indexed | 2024-03-10T03:38:09Z |
| format | Article |
| id | doaj.art-f02b9a7205e04ef4aeaf84df39547cae |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:38:09Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f02b9a7205e04ef4aeaf84df39547cae2023-11-23T11:41:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123156210.3390/ijms23010562Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory ProteinsJannette Carey0Chemistry Department, Princeton University, Princeton, NJ 08544, USANearly all of biology depends on interactions between molecules: proteins with small molecules, proteins with other proteins, nucleic acids with small molecules, and nucleic acids with proteins that regulate gene expression, our concern in this Special Issue. All those kinds of interactions, and others, constitute the vast majority of biology at the molecular level. An understanding of those interactions requires that we quantify them to learn how they interact: How strongly? With which partners? How—and how well—are different partners distinguished? This review addresses the evolution of our current understanding of the molecular origins of affinity and specificity in regulatory protein–DNA interactions, and suggests that both these properties can be modulated by cooperativity.https://www.mdpi.com/1422-0067/23/1/562biological constraintshost–guest chemistrypre-organizationcryptic thermodynamic factorsprotein folding coupled to ligand bindinggestalt properties of proteins |
| spellingShingle | Jannette Carey Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins International Journal of Molecular Sciences biological constraints host–guest chemistry pre-organization cryptic thermodynamic factors protein folding coupled to ligand binding gestalt properties of proteins |
| title | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
| title_full | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
| title_fullStr | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
| title_full_unstemmed | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
| title_short | Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins |
| title_sort | affinity specificity and cooperativity of dna binding by bacterial gene regulatory proteins |
| topic | biological constraints host–guest chemistry pre-organization cryptic thermodynamic factors protein folding coupled to ligand binding gestalt properties of proteins |
| url | https://www.mdpi.com/1422-0067/23/1/562 |
| work_keys_str_mv | AT jannettecarey affinityspecificityandcooperativityofdnabindingbybacterialgeneregulatoryproteins |