Downregulation of Tumour Necrosis Factor α Gene Expression in Peripheral Blood Mononuclear Cells Cultured in the Presence of Tofacitinib Prior to Therapy Is Associated with Clinical Remission in Patients with Rheumatoid Arthritis

Downregulation of Tumour Necrosis Factor α Gene Expression in Peripheral Blood Mononuclear Cells Cultured in the Presence of Tofacitinib Prior to Therapy Is Associated with Clinical Remission in Patients with Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by pain, synovial hyperplasia, mononuclear cell infiltration, bone erosion and joint destruction. Efficacy of personalized therapy in RA is associated with correct choice of therapeutic agent and a possibility to predict its e...

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Bibliographic Details
Main Authors: Elena V. Tchetina, Galina A. Markova, Azamat M. Satybaldyev, Aleksandr M. Lila
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Current Issues in Molecular Biology
Subjects:
rheumatoid arthritis
tofacitinib
gene expression
cultured peripheral blood mononuclear cells
prognostic biomarkers
TNFα
Online Access:https://www.mdpi.com/1467-3045/44/5/132

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