Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China
Abstract Aims/Introduction Metals play an important role in diabetes mellitus. This cross‐sectional study aimed to evaluate the overall, individual and interactive effects of multi‐metal exposure on the prevalence of diabetes mellitus, impaired fasting glucose (IFG) rate and fasting blood glucose (F...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13797 |
| _version_ | 1811221628910043136 |
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| author | Jing Zhang Huanhuan Yin Xuemei Zhu Rong Xiang Yeqiu Miao Yu Zhang Yang Song Jinyao Chen Lishi Zhang |
| author_facet | Jing Zhang Huanhuan Yin Xuemei Zhu Rong Xiang Yeqiu Miao Yu Zhang Yang Song Jinyao Chen Lishi Zhang |
| author_sort | Jing Zhang |
| collection | DOAJ |
| description | Abstract Aims/Introduction Metals play an important role in diabetes mellitus. This cross‐sectional study aimed to evaluate the overall, individual and interactive effects of multi‐metal exposure on the prevalence of diabetes mellitus, impaired fasting glucose (IFG) rate and fasting blood glucose (FBG) levels. Materials and Methods The FBG levels of a study population from a cadmium (Cd)‐polluted area (n = 250) and an unpolluted area (n = 204), and the metal levels, including magnesium, calcium (Ca), iron (Fe), zinc (Zn), arsenic (As), Cd, copper and lead (Pb) in blood and urine were detected. The study population was divided into a normal fasting glucose group, an IFG group and a diabetes mellitus group on the basis of FBG levels. Results The IFG rate and diabetes mellitus prevalence were negatively associated with blood Cd and urine Zn levels (IFG rate: odds ratio [OR] 0.780, 95% confidence interval [CI] 0.655–0.928; OR 0.622, 95% CI 0.465–0.831. Diabetes mellitus prevalence: OR 0.506, 95% CI 0.288–0.888; OR 0.609, 95% CI 0.395–0.939), the IFG rate was positively associated with urine Fe levels (OR 1.876, 95% CI 1.290–2.778), and diabetes mellitus prevalence was positively associated with urine Pb and blood Fe levels (OR 1.185, 95% CI 1.022–1.376; OR 1.008, 95% CI 1.001–1.014). A linear negative correlation was observed between FBG levels and blood Cd, and non‐linear inverted U‐shaped associations were found between FBG levels and Zn, Pb and copper in urine. Conclusions This research suggests that multi‐metal exposure, especially Cd, Fe, Zn, copper and Pb, is linked to diabetes mellitus, and the interactive effects of multiple metals require further exploration. |
| first_indexed | 2024-04-12T08:03:58Z |
| format | Article |
| id | doaj.art-f02cffb6324e456797ec1c9f0c18d4dd |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-04-12T08:03:58Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-f02cffb6324e456797ec1c9f0c18d4dd2022-12-22T03:41:15ZengWileyJournal of Diabetes Investigation2040-11162040-11242022-08-011381412142510.1111/jdi.13797Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest ChinaJing Zhang0Huanhuan Yin1Xuemei Zhu2Rong Xiang3Yeqiu Miao4Yu Zhang5Yang Song6Jinyao Chen7Lishi Zhang8West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaWest China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaWest China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaWest China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaWest China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaDepartment of Nutrition and Food Safety Sichuan Center for Disease Control and Prevention Chengdu ChinaDepartment of Nutrition and Food Safety Sichuan Center for Disease Control and Prevention Chengdu ChinaWest China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaWest China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaAbstract Aims/Introduction Metals play an important role in diabetes mellitus. This cross‐sectional study aimed to evaluate the overall, individual and interactive effects of multi‐metal exposure on the prevalence of diabetes mellitus, impaired fasting glucose (IFG) rate and fasting blood glucose (FBG) levels. Materials and Methods The FBG levels of a study population from a cadmium (Cd)‐polluted area (n = 250) and an unpolluted area (n = 204), and the metal levels, including magnesium, calcium (Ca), iron (Fe), zinc (Zn), arsenic (As), Cd, copper and lead (Pb) in blood and urine were detected. The study population was divided into a normal fasting glucose group, an IFG group and a diabetes mellitus group on the basis of FBG levels. Results The IFG rate and diabetes mellitus prevalence were negatively associated with blood Cd and urine Zn levels (IFG rate: odds ratio [OR] 0.780, 95% confidence interval [CI] 0.655–0.928; OR 0.622, 95% CI 0.465–0.831. Diabetes mellitus prevalence: OR 0.506, 95% CI 0.288–0.888; OR 0.609, 95% CI 0.395–0.939), the IFG rate was positively associated with urine Fe levels (OR 1.876, 95% CI 1.290–2.778), and diabetes mellitus prevalence was positively associated with urine Pb and blood Fe levels (OR 1.185, 95% CI 1.022–1.376; OR 1.008, 95% CI 1.001–1.014). A linear negative correlation was observed between FBG levels and blood Cd, and non‐linear inverted U‐shaped associations were found between FBG levels and Zn, Pb and copper in urine. Conclusions This research suggests that multi‐metal exposure, especially Cd, Fe, Zn, copper and Pb, is linked to diabetes mellitus, and the interactive effects of multiple metals require further exploration.https://doi.org/10.1111/jdi.13797Diabetes mellitusImpaired fasting glucoseMulti‐metal exposure |
| spellingShingle | Jing Zhang Huanhuan Yin Xuemei Zhu Rong Xiang Yeqiu Miao Yu Zhang Yang Song Jinyao Chen Lishi Zhang Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China Journal of Diabetes Investigation Diabetes mellitus Impaired fasting glucose Multi‐metal exposure |
| title | Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China |
| title_full | Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China |
| title_fullStr | Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China |
| title_full_unstemmed | Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China |
| title_short | Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China |
| title_sort | effects of multi metal exposure on the risk of diabetes mellitus among people aged 40 75 years in rural areas in southwest china |
| topic | Diabetes mellitus Impaired fasting glucose Multi‐metal exposure |
| url | https://doi.org/10.1111/jdi.13797 |
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