The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of Alzheimer’s disease (AD). Despite considerable interest in developing γ-secretase targeting therapeutics f...

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Bibliographic Details
Main Authors:	David M Bolduc, Daniel R Montagna, Matthew C Seghers, Michael S Wolfe, Dennis J Selkoe
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2016-08-01
Series:	eLife
Subjects:	gamma-secretase amyloid beta intramembrane protease Alzheimer's disease
Online Access:	https://elifesciences.org/articles/17578

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