Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/64327 |
| _version_ | 1811180578896084992 |
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| author | Hongdian Yang Bilal A Bari Jeremiah Y Cohen Daniel H O'Connor |
| author_facet | Hongdian Yang Bilal A Bari Jeremiah Y Cohen Daniel H O'Connor |
| author_sort | Hongdian Yang |
| collection | DOAJ |
| description | We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity. |
| first_indexed | 2024-04-11T09:05:33Z |
| format | Article |
| id | doaj.art-f032669c3f2f4afeb8f255cb412d5cdf |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:33Z |
| publishDate | 2021-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f032669c3f2f4afeb8f255cb412d5cdf2022-12-22T04:32:39ZengeLife Sciences Publications LtdeLife2050-084X2021-03-011010.7554/eLife.64327Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection taskHongdian Yang0https://orcid.org/0000-0002-5203-9519Bilal A Bari1Jeremiah Y Cohen2https://orcid.org/0000-0002-4768-7124Daniel H O'Connor3https://orcid.org/0000-0002-9193-6714Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United StatesDepartment of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, United StatesDepartment of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, United StatesDepartment of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, United StatesWe examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.https://elifesciences.org/articles/64327locus coeruleustactilepupilsomatosensory cortexS1norepinephrine |
| spellingShingle | Hongdian Yang Bilal A Bari Jeremiah Y Cohen Daniel H O'Connor Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task eLife locus coeruleus tactile pupil somatosensory cortex S1 norepinephrine |
| title | Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task |
| title_full | Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task |
| title_fullStr | Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task |
| title_full_unstemmed | Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task |
| title_short | Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task |
| title_sort | locus coeruleus spiking differently correlates with s1 cortex activity and pupil diameter in a tactile detection task |
| topic | locus coeruleus tactile pupil somatosensory cortex S1 norepinephrine |
| url | https://elifesciences.org/articles/64327 |
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