Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice
Alzheimer’s disease (AD), the most prevalent neurodegenerative disease, is characterized by progressive and irreversible impairment of cognitive functions. However, its etiology is poorly understood, and therapeutic interventions are limited. Our preliminary study revealed that wasp venom (WV) from...
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MDPI AG
2023-03-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/15/3/203 |
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| author | Yoon Ah Jeong Hyun Seok Yun Yoonsu Kim Chan Ho Jang Ji Sun Lim Hyo Jung Kim Moon Bo Choi Jae Woo Jung Jisun Oh Jong-Sang Kim |
| author_facet | Yoon Ah Jeong Hyun Seok Yun Yoonsu Kim Chan Ho Jang Ji Sun Lim Hyo Jung Kim Moon Bo Choi Jae Woo Jung Jisun Oh Jong-Sang Kim |
| author_sort | Yoon Ah Jeong |
| collection | DOAJ |
| description | Alzheimer’s disease (AD), the most prevalent neurodegenerative disease, is characterized by progressive and irreversible impairment of cognitive functions. However, its etiology is poorly understood, and therapeutic interventions are limited. Our preliminary study revealed that wasp venom (WV) from <i>Vespa velutina nigrithorax</i> can prevent lipopolysaccharide-induced inflammatory signaling, which is strongly implicated in AD pathogenesis. Therefore, we examined whether WV administration can ameliorate major AD phenotypes in the 5xFAD transgenic mouse model. Adult 5xFAD transgenic mice (6.5 months of age) were treated with WV by intraperitoneal injection at 250 or 400 μg/kg body weight once weekly for 14 consecutive weeks. This administration regimen improved procedural, spatial, and working memory deficits as assessed by the passive avoidance, Morris water maze, and Y-maze tasks, respectively. It also attenuated histological damage and amyloid-beta plaque formation in the hippocampal region and decreased expression levels of pro-inflammatory factors in the hippocampus and cerebrum, while it reduced oxidative stress markers (malondialdehyde in the brain and liver and 8-hydroxy-2′-deoxyguanosine in the plasma). Overall, these findings suggest that long-term administration of WV may alleviate AD-related symptoms and pathological phenotypes. |
| first_indexed | 2024-03-11T05:49:45Z |
| format | Article |
| id | doaj.art-f0336ef54811408188b4519a95401a39 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-11T05:49:45Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-f0336ef54811408188b4519a95401a392023-11-17T14:14:18ZengMDPI AGToxins2072-66512023-03-0115320310.3390/toxins15030203Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic MiceYoon Ah Jeong0Hyun Seok Yun1Yoonsu Kim2Chan Ho Jang3Ji Sun Lim4Hyo Jung Kim5Moon Bo Choi6Jae Woo Jung7Jisun Oh8Jong-Sang Kim9School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of KoreaSchool of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of KoreaDepartment of Integrative Biology, Kyungpook National University, Daegu 41566, Republic of KoreaInstitute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Republic of KoreaDepartment of Nuclear Medicine, Keimyung University Dongsan Hospital, Daegu 42601, Republic of KoreaKorean Medicine Material Development Center, National Institute for Korean Medicine Development, Gyeongsan 38540, Republic of KoreaInstitute of Plant Medicine, Kyungpook National University, Daegu 41566, Republic of KoreaExternal Herbal Dispensaries (BEEPLUS), Wonjae Oriental Medicine Clinic, Chilgok-gun 718807, Gyeongsangbuk-do, Republic of KoreaNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of KoreaSchool of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of KoreaAlzheimer’s disease (AD), the most prevalent neurodegenerative disease, is characterized by progressive and irreversible impairment of cognitive functions. However, its etiology is poorly understood, and therapeutic interventions are limited. Our preliminary study revealed that wasp venom (WV) from <i>Vespa velutina nigrithorax</i> can prevent lipopolysaccharide-induced inflammatory signaling, which is strongly implicated in AD pathogenesis. Therefore, we examined whether WV administration can ameliorate major AD phenotypes in the 5xFAD transgenic mouse model. Adult 5xFAD transgenic mice (6.5 months of age) were treated with WV by intraperitoneal injection at 250 or 400 μg/kg body weight once weekly for 14 consecutive weeks. This administration regimen improved procedural, spatial, and working memory deficits as assessed by the passive avoidance, Morris water maze, and Y-maze tasks, respectively. It also attenuated histological damage and amyloid-beta plaque formation in the hippocampal region and decreased expression levels of pro-inflammatory factors in the hippocampus and cerebrum, while it reduced oxidative stress markers (malondialdehyde in the brain and liver and 8-hydroxy-2′-deoxyguanosine in the plasma). Overall, these findings suggest that long-term administration of WV may alleviate AD-related symptoms and pathological phenotypes.https://www.mdpi.com/2072-6651/15/3/203wasp venom<i>Vespa velutina nigrithorax</i>Alzheimer’s disease5xFAD mousememory improvementanti-inflammation |
| spellingShingle | Yoon Ah Jeong Hyun Seok Yun Yoonsu Kim Chan Ho Jang Ji Sun Lim Hyo Jung Kim Moon Bo Choi Jae Woo Jung Jisun Oh Jong-Sang Kim Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice Toxins wasp venom <i>Vespa velutina nigrithorax</i> Alzheimer’s disease 5xFAD mouse memory improvement anti-inflammation |
| title | Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice |
| title_full | Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice |
| title_fullStr | Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice |
| title_full_unstemmed | Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice |
| title_short | Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice |
| title_sort | long term administration of i vespa velutina nigrithorax i venom ameliorates alzheimer s phenotypes in 5xfad transgenic mice |
| topic | wasp venom <i>Vespa velutina nigrithorax</i> Alzheimer’s disease 5xFAD mouse memory improvement anti-inflammation |
| url | https://www.mdpi.com/2072-6651/15/3/203 |
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