Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes
Evidence indicates that different pathways of malignant degeneration underlie the development of endometriosis-associated ovarian tumors of endometrioid and clear cell histotypes. The aim of this study was to compare data from patients affected by these two histotypes to investigate the hypothesis o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/8/1425 |
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| author | Alice Bergamini Giorgia Mangili Alessandro Ambrosi Gianluca Taccagni Emanuela Rabaiotti Luca Bocciolone Giorgio Candotti Raffaella Cioffi Francesca Pella Giulia Sabetta Costanza Saponaro Massimo Candiani |
| author_facet | Alice Bergamini Giorgia Mangili Alessandro Ambrosi Gianluca Taccagni Emanuela Rabaiotti Luca Bocciolone Giorgio Candotti Raffaella Cioffi Francesca Pella Giulia Sabetta Costanza Saponaro Massimo Candiani |
| author_sort | Alice Bergamini |
| collection | DOAJ |
| description | Evidence indicates that different pathways of malignant degeneration underlie the development of endometriosis-associated ovarian tumors of endometrioid and clear cell histotypes. The aim of this study was to compare data from patients affected by these two histotypes to investigate the hypothesis of a dichotomy in the histogenesis of these tumors. Clinical data and tumor characteristics of 48 patients who were diagnosed with either pure clear cell ovarian cancer and mixed endometrioid–clear cell ovarian cancer arising from endometriosis (ECC, <i>n</i> = 22) or endometriosis-associated endometrioid ovarian cancer (EAEOC, <i>n</i> = 26) were compared. A previous diagnosis of endometriosis was detected more frequently in the ECC group (32% vs. 4%, <i>p</i> = 0.01). The incidence of bilaterality was significantly higher in the EAOEC group (35% vs. 5%, <i>p</i> = 0.01) as well as a solid/cystic rate at gross pathology (57.7 ± 7.9% vs. 30.9 ± 7.5%, <i>p</i> = 0.02). Patients with ECC had a more advanced disease stage (41% vs. 15%; <i>p</i> = 0.04). A synchronous endometrial carcinoma was detected in 38% of EAEOC patients. A comparison of the International Federation of Gynecology and Obstetrics (FIGO) stage at diagnosis showed a significantly decreasing trend for ECC compared to EAEOC (<i>p</i> = 0.02). These findings support the hypothesis that the origin, clinical behavior and relationship with endometriosis might be different for these histotypes. ECC, unlike EAEOC, seems to develop within an endometriotic cyst, thus representing a window of possibility for ultrasound-based early diagnosis. |
| first_indexed | 2024-03-11T05:06:35Z |
| format | Article |
| id | doaj.art-f033d568d43349d8aedbb5ed70a41d50 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T05:06:35Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f033d568d43349d8aedbb5ed70a41d502023-11-17T18:54:54ZengMDPI AGDiagnostics2075-44182023-04-01138142510.3390/diagnostics13081425Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated HistotypesAlice Bergamini0Giorgia Mangili1Alessandro Ambrosi2Gianluca Taccagni3Emanuela Rabaiotti4Luca Bocciolone5Giorgio Candotti6Raffaella Cioffi7Francesca Pella8Giulia Sabetta9Costanza Saponaro10Massimo Candiani11Obstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, ItalySurgical Pathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyEvidence indicates that different pathways of malignant degeneration underlie the development of endometriosis-associated ovarian tumors of endometrioid and clear cell histotypes. The aim of this study was to compare data from patients affected by these two histotypes to investigate the hypothesis of a dichotomy in the histogenesis of these tumors. Clinical data and tumor characteristics of 48 patients who were diagnosed with either pure clear cell ovarian cancer and mixed endometrioid–clear cell ovarian cancer arising from endometriosis (ECC, <i>n</i> = 22) or endometriosis-associated endometrioid ovarian cancer (EAEOC, <i>n</i> = 26) were compared. A previous diagnosis of endometriosis was detected more frequently in the ECC group (32% vs. 4%, <i>p</i> = 0.01). The incidence of bilaterality was significantly higher in the EAOEC group (35% vs. 5%, <i>p</i> = 0.01) as well as a solid/cystic rate at gross pathology (57.7 ± 7.9% vs. 30.9 ± 7.5%, <i>p</i> = 0.02). Patients with ECC had a more advanced disease stage (41% vs. 15%; <i>p</i> = 0.04). A synchronous endometrial carcinoma was detected in 38% of EAEOC patients. A comparison of the International Federation of Gynecology and Obstetrics (FIGO) stage at diagnosis showed a significantly decreasing trend for ECC compared to EAEOC (<i>p</i> = 0.02). These findings support the hypothesis that the origin, clinical behavior and relationship with endometriosis might be different for these histotypes. ECC, unlike EAEOC, seems to develop within an endometriotic cyst, thus representing a window of possibility for ultrasound-based early diagnosis.https://www.mdpi.com/2075-4418/13/8/1425ovarian cancerendometrioid ovarian cancerclear cell ovarian cancerendometriosiscarcinogenesis |
| spellingShingle | Alice Bergamini Giorgia Mangili Alessandro Ambrosi Gianluca Taccagni Emanuela Rabaiotti Luca Bocciolone Giorgio Candotti Raffaella Cioffi Francesca Pella Giulia Sabetta Costanza Saponaro Massimo Candiani Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes Diagnostics ovarian cancer endometrioid ovarian cancer clear cell ovarian cancer endometriosis carcinogenesis |
| title | Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes |
| title_full | Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes |
| title_fullStr | Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes |
| title_full_unstemmed | Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes |
| title_short | Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes |
| title_sort | endometriosis related ovarian cancers evidence for a dichotomy in the histogenesis of the two associated histotypes |
| topic | ovarian cancer endometrioid ovarian cancer clear cell ovarian cancer endometriosis carcinogenesis |
| url | https://www.mdpi.com/2075-4418/13/8/1425 |
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