Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase
The presence of cancer can induce systemic disruption of the host homeostasis. Here, the authors show that different solid tumours remotely increase hepatic nicotinamide-Nmethyltransferase disrupting the host urea cycle metabolism in the liver.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30926-z |
| _version_ | 1811242247602044928 |
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| author | Rin Mizuno Hiroaki Hojo Masatomo Takahashi Soshiro Kashio Sora Enya Motonao Nakao Riyo Konishi Mayuko Yoda Ayano Harata Junzo Hamanishi Hiroshi Kawamoto Masaki Mandai Yutaka Suzuki Masayuki Miura Takeshi Bamba Yoshihiro Izumi Shinpei Kawaoka |
| author_facet | Rin Mizuno Hiroaki Hojo Masatomo Takahashi Soshiro Kashio Sora Enya Motonao Nakao Riyo Konishi Mayuko Yoda Ayano Harata Junzo Hamanishi Hiroshi Kawamoto Masaki Mandai Yutaka Suzuki Masayuki Miura Takeshi Bamba Yoshihiro Izumi Shinpei Kawaoka |
| author_sort | Rin Mizuno |
| collection | DOAJ |
| description | The presence of cancer can induce systemic disruption of the host homeostasis. Here, the authors show that different solid tumours remotely increase hepatic nicotinamide-Nmethyltransferase disrupting the host urea cycle metabolism in the liver. |
| first_indexed | 2024-04-12T13:48:55Z |
| format | Article |
| id | doaj.art-f033da34790f4530b76d6f748729332a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T13:48:55Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f033da34790f4530b76d6f748729332a2022-12-22T03:30:36ZengNature PortfolioNature Communications2041-17232022-06-0113111310.1038/s41467-022-30926-zRemote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferaseRin Mizuno0Hiroaki Hojo1Masatomo Takahashi2Soshiro Kashio3Sora Enya4Motonao Nakao5Riyo Konishi6Mayuko Yoda7Ayano Harata8Junzo Hamanishi9Hiroshi Kawamoto10Masaki Mandai11Yutaka Suzuki12Masayuki Miura13Takeshi Bamba14Yoshihiro Izumi15Shinpei Kawaoka16Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto UniversityInter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto UniversityDivision of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu UniversityDepartment of Genetics, Graduate School of Pharmaceutical Sciences, The University of TokyoThe Thomas N. Sato BioMEC-X Laboratories, Advanced Telecommunications Research Institute International (ATR)Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu UniversityInter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto UniversityInter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto UniversityInter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto UniversityDepartment of Gynecology and Obstetrics, Kyoto University Graduate School of MedicineLaboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto UniversityDepartment of Gynecology and Obstetrics, Kyoto University Graduate School of MedicineGraduate School of Frontier Science, The University of TokyoDepartment of Genetics, Graduate School of Pharmaceutical Sciences, The University of TokyoDivision of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu UniversityDivision of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu UniversityInter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto UniversityThe presence of cancer can induce systemic disruption of the host homeostasis. Here, the authors show that different solid tumours remotely increase hepatic nicotinamide-Nmethyltransferase disrupting the host urea cycle metabolism in the liver.https://doi.org/10.1038/s41467-022-30926-z |
| spellingShingle | Rin Mizuno Hiroaki Hojo Masatomo Takahashi Soshiro Kashio Sora Enya Motonao Nakao Riyo Konishi Mayuko Yoda Ayano Harata Junzo Hamanishi Hiroshi Kawamoto Masaki Mandai Yutaka Suzuki Masayuki Miura Takeshi Bamba Yoshihiro Izumi Shinpei Kawaoka Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase Nature Communications |
| title | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase |
| title_full | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase |
| title_fullStr | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase |
| title_full_unstemmed | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase |
| title_short | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase |
| title_sort | remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide n methyltransferase |
| url | https://doi.org/10.1038/s41467-022-30926-z |
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