Phage phiKZ—The First of Giants
The paper covers the history of the discovery and description of phiKZ, the first known giant bacteriophage active on <i>Pseudomonas aeruginosa</i>. It also describes its unique features, especially the characteristic manner of DNA packing in the head around a cylinder-shaped structure (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/2/149 |
| _version_ | 1827599324257714176 |
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| author | Victor Krylov Maria Bourkaltseva Elena Pleteneva Olga Shaburova Sergey Krylov Alexander Karaulov Sergey Zhavoronok Oxana Svitich Vitaly Zverev |
| author_facet | Victor Krylov Maria Bourkaltseva Elena Pleteneva Olga Shaburova Sergey Krylov Alexander Karaulov Sergey Zhavoronok Oxana Svitich Vitaly Zverev |
| author_sort | Victor Krylov |
| collection | DOAJ |
| description | The paper covers the history of the discovery and description of phiKZ, the first known giant bacteriophage active on <i>Pseudomonas aeruginosa</i>. It also describes its unique features, especially the characteristic manner of DNA packing in the head around a cylinder-shaped structure (“inner body”), which probably governs an ordered and tight packaging of the phage genome. Important properties of phiKZ-like phages include a wide range of lytic activity and the blue opalescence of their negative colonies, and provide a background for the search and discovery of new <i>P. aeruginosa</i> giant phages. The importance of the phiKZ species and of other giant phage species in practical phage therapy is noted given their broad use in commercial phage preparations. |
| first_indexed | 2024-03-09T04:10:11Z |
| format | Article |
| id | doaj.art-f034e76ec04647da93c0e457455eac83 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T04:10:11Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f034e76ec04647da93c0e457455eac832023-12-03T14:01:17ZengMDPI AGViruses1999-49152021-01-0113214910.3390/v13020149Phage phiKZ—The First of GiantsVictor Krylov0Maria Bourkaltseva1Elena Pleteneva2Olga Shaburova3Sergey Krylov4Alexander Karaulov5Sergey Zhavoronok6Oxana Svitich7Vitaly Zverev8I.I. Mechnikov Research Institute of Vaccines & Sera, 105064 Moscow, RussiaI.I. Mechnikov Research Institute of Vaccines & Sera, 105064 Moscow, RussiaI.I. Mechnikov Research Institute of Vaccines & Sera, 105064 Moscow, RussiaI.I. Mechnikov Research Institute of Vaccines & Sera, 105064 Moscow, RussiaI.I. Mechnikov Research Institute of Vaccines & Sera, 105064 Moscow, RussiaDepartment of Clinical Immunology and Allergy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, 119146 Moscow, RussiaDepartment of Infectious Diseases, Belarusian State Medical University, 220116 Minsk, BelarusI.I. Mechnikov Research Institute of Vaccines & Sera, 105064 Moscow, RussiaI.I. Mechnikov Research Institute of Vaccines & Sera, 105064 Moscow, RussiaThe paper covers the history of the discovery and description of phiKZ, the first known giant bacteriophage active on <i>Pseudomonas aeruginosa</i>. It also describes its unique features, especially the characteristic manner of DNA packing in the head around a cylinder-shaped structure (“inner body”), which probably governs an ordered and tight packaging of the phage genome. Important properties of phiKZ-like phages include a wide range of lytic activity and the blue opalescence of their negative colonies, and provide a background for the search and discovery of new <i>P. aeruginosa</i> giant phages. The importance of the phiKZ species and of other giant phage species in practical phage therapy is noted given their broad use in commercial phage preparations.https://www.mdpi.com/1999-4915/13/2/149giant phagesphage phiKZphage particles structureinner body<i>Pseudomonas</i>pseudolysogeny |
| spellingShingle | Victor Krylov Maria Bourkaltseva Elena Pleteneva Olga Shaburova Sergey Krylov Alexander Karaulov Sergey Zhavoronok Oxana Svitich Vitaly Zverev Phage phiKZ—The First of Giants Viruses giant phages phage phiKZ phage particles structure inner body <i>Pseudomonas</i> pseudolysogeny |
| title | Phage phiKZ—The First of Giants |
| title_full | Phage phiKZ—The First of Giants |
| title_fullStr | Phage phiKZ—The First of Giants |
| title_full_unstemmed | Phage phiKZ—The First of Giants |
| title_short | Phage phiKZ—The First of Giants |
| title_sort | phage phikz the first of giants |
| topic | giant phages phage phiKZ phage particles structure inner body <i>Pseudomonas</i> pseudolysogeny |
| url | https://www.mdpi.com/1999-4915/13/2/149 |
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