Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder
Autism spectrum disorder (ASD), with its high economic and societal costs, is a growing public health concern whose prevalence has risen steadily over the last two decades. Although actual increased incidence versus improved diagnosis remains controversial, the increased prevalence of ASD suggests n...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2022-12-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2022-1598.pdf |
| _version_ | 1797962316037226496 |
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| author | Hyeong-Moo Shin Jiwon Oh Rebecca J. Schmidt Elizabeth N. Pearce |
| author_facet | Hyeong-Moo Shin Jiwon Oh Rebecca J. Schmidt Elizabeth N. Pearce |
| author_sort | Hyeong-Moo Shin |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD), with its high economic and societal costs, is a growing public health concern whose prevalence has risen steadily over the last two decades. Although actual increased incidence versus improved diagnosis remains controversial, the increased prevalence of ASD suggests non-inherited factors as likely contributors. There is increasing epidemiologic evidence that abnormal maternal thyroid function during pregnancy is associated with increased risk of child ASD and other neurodevelopmental disorders. Prenatal exposure to endocrine-disrupting chemicals such as per- and polyfluoroalkyl substances (PFAS) is known to disrupt thyroid function and can affect early brain development; thus, thyroid dysfunction is hypothesized to mediate this relationship. The concept of a potential pathway from prenatal PFAS exposure through thyroid dysfunction to ASD etiology is not new; however, the extant literature on this topic is scant. The aim of this review is to evaluate and summarize reports with regard to potential mechanisms in this pathway. |
| first_indexed | 2024-04-11T01:11:24Z |
| format | Article |
| id | doaj.art-f03687d40e684979bebd92afb74c58d8 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-11T01:11:24Z |
| publishDate | 2022-12-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-f03687d40e684979bebd92afb74c58d82023-01-04T05:41:52ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782022-12-0137681982910.3803/EnM.2022.15982347Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum DisorderHyeong-Moo Shin0Jiwon Oh1Rebecca J. Schmidt2Elizabeth N. Pearce3 Department of Environmental Science, Baylor University, Waco, TX, USA Department of Public Health Sciences, University of California, Davis, CA, USA Department of Public Health Sciences, University of California, Davis, CA, USA Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USAAutism spectrum disorder (ASD), with its high economic and societal costs, is a growing public health concern whose prevalence has risen steadily over the last two decades. Although actual increased incidence versus improved diagnosis remains controversial, the increased prevalence of ASD suggests non-inherited factors as likely contributors. There is increasing epidemiologic evidence that abnormal maternal thyroid function during pregnancy is associated with increased risk of child ASD and other neurodevelopmental disorders. Prenatal exposure to endocrine-disrupting chemicals such as per- and polyfluoroalkyl substances (PFAS) is known to disrupt thyroid function and can affect early brain development; thus, thyroid dysfunction is hypothesized to mediate this relationship. The concept of a potential pathway from prenatal PFAS exposure through thyroid dysfunction to ASD etiology is not new; however, the extant literature on this topic is scant. The aim of this review is to evaluate and summarize reports with regard to potential mechanisms in this pathway.http://www.e-enm.org/upload/pdf/enm-2022-1598.pdfantibodiesautism spectrum disorderendocrine disrupting chemicalsenvironmental exposurepregnancythyroid |
| spellingShingle | Hyeong-Moo Shin Jiwon Oh Rebecca J. Schmidt Elizabeth N. Pearce Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder Endocrinology and Metabolism antibodies autism spectrum disorder endocrine disrupting chemicals environmental exposure pregnancy thyroid |
| title | Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder |
| title_full | Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder |
| title_fullStr | Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder |
| title_full_unstemmed | Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder |
| title_short | Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder |
| title_sort | prenatal exposure to per and polyfluoroalkyl substances maternal thyroid dysfunction and child autism spectrum disorder |
| topic | antibodies autism spectrum disorder endocrine disrupting chemicals environmental exposure pregnancy thyroid |
| url | http://www.e-enm.org/upload/pdf/enm-2022-1598.pdf |
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