Effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory-confirmed avian influenza A H7N9
Objectives: Avian influenza virus A(H7N9) remains a threat to humans and has great potential to cause a pandemic in the foreseeable future. Antiviral treatment with neuraminidase inhibitors has been recommended to treat patients with H7N9 infection as early as possible, although evidence-based resea...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220325510 |
| _version_ | 1818457617424449536 |
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| author | Wei Cheng Anqi Pan Stephen L. Rathbun Yang Ge Qian Xiao Leonardo Martinez Feng Ling Shelan Liu Xiaoxiao Wang Zhao Yu Mark H. Ebell Changwei Li Andreas Handel Enfu Chen Ye Shen |
| author_facet | Wei Cheng Anqi Pan Stephen L. Rathbun Yang Ge Qian Xiao Leonardo Martinez Feng Ling Shelan Liu Xiaoxiao Wang Zhao Yu Mark H. Ebell Changwei Li Andreas Handel Enfu Chen Ye Shen |
| author_sort | Wei Cheng |
| collection | DOAJ |
| description | Objectives: Avian influenza virus A(H7N9) remains a threat to humans and has great potential to cause a pandemic in the foreseeable future. Antiviral treatment with neuraminidase inhibitors has been recommended to treat patients with H7N9 infection as early as possible, although evidence-based research on their effectiveness for H7N9 infection is lacking. Methods: Data from all laboratory-confirmed cases of H7N9 infection in Zhejiang Province between 2013 and 2017 were retrieved, and time-dependent survival models were used to evaluate the effectiveness of treatment with neuraminidase inhibitors to reduce the risk of mortality. Results: The final optimal model found no significant association (odds ratio 1.29, 95% confidence interval 0.78–2.15) between time to treatment with neuraminidase inhibitors and survival after controlling for age and white blood cell count. Sensitivity analyses with multiple imputation for missing data concurred with the primary analysis. Conclusions: No association was found between treatment with neuraminidase inhibitors and survival in patients with H7N9 infection using various adjusted models and sensitivity analyses of missing data imputations. |
| first_indexed | 2024-12-14T22:45:25Z |
| format | Article |
| id | doaj.art-f03897b8f23e42d780164c3d22192cb3 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-14T22:45:25Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-f03897b8f23e42d780164c3d22192cb32022-12-21T22:44:51ZengElsevierInternational Journal of Infectious Diseases1201-97122021-02-01103573578Effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory-confirmed avian influenza A H7N9Wei Cheng0Anqi Pan1Stephen L. Rathbun2Yang Ge3Qian Xiao4Leonardo Martinez5Feng Ling6Shelan Liu7Xiaoxiao Wang8Zhao Yu9Mark H. Ebell10Changwei Li11Andreas Handel12Enfu Chen13Ye Shen14Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, ChinaUniversity of Georgia, College of Public Health, Department of Epidemiology and Biostatistics, Athens, GA, USAUniversity of Georgia, College of Public Health, Department of Epidemiology and Biostatistics, Athens, GA, USAUniversity of Georgia, College of Public Health, Department of Epidemiology and Biostatistics, Athens, GA, USAUniversity of Georgia, Department of Statistics, Athens, GA, USAStanford University, School of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford, CA, USAZhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, ChinaUniversity of Georgia, College of Public Health, Department of Epidemiology and Biostatistics, Athens, GA, USAUniversity of Georgia, College of Public Health, Department of Epidemiology and Biostatistics, Athens, GA, USA; Tulane University School of Public Health and Tropical Medicine, Department of Epidemiology, New Orleans, LA, USAUniversity of Georgia, College of Public Health, Department of Epidemiology and Biostatistics, Athens, GA, USA; University of Georgia, College of Public Health, Health Informatics Institute, Athens, GA, USA; University of Georgia, Center for the Ecology of Infectious Diseases, Athens, GA, USAZhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, ChinaUniversity of Georgia, College of Public Health, Department of Epidemiology and Biostatistics, Athens, GA, USA; Corresponding author at: University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics, 105 Spear Rd, Athens, GA 30602, USA.Objectives: Avian influenza virus A(H7N9) remains a threat to humans and has great potential to cause a pandemic in the foreseeable future. Antiviral treatment with neuraminidase inhibitors has been recommended to treat patients with H7N9 infection as early as possible, although evidence-based research on their effectiveness for H7N9 infection is lacking. Methods: Data from all laboratory-confirmed cases of H7N9 infection in Zhejiang Province between 2013 and 2017 were retrieved, and time-dependent survival models were used to evaluate the effectiveness of treatment with neuraminidase inhibitors to reduce the risk of mortality. Results: The final optimal model found no significant association (odds ratio 1.29, 95% confidence interval 0.78–2.15) between time to treatment with neuraminidase inhibitors and survival after controlling for age and white blood cell count. Sensitivity analyses with multiple imputation for missing data concurred with the primary analysis. Conclusions: No association was found between treatment with neuraminidase inhibitors and survival in patients with H7N9 infection using various adjusted models and sensitivity analyses of missing data imputations.http://www.sciencedirect.com/science/article/pii/S1201971220325510H7N9 infectionInfluenzaMortalityNeuraminidase inhibitorsEffectiveness |
| spellingShingle | Wei Cheng Anqi Pan Stephen L. Rathbun Yang Ge Qian Xiao Leonardo Martinez Feng Ling Shelan Liu Xiaoxiao Wang Zhao Yu Mark H. Ebell Changwei Li Andreas Handel Enfu Chen Ye Shen Effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory-confirmed avian influenza A H7N9 International Journal of Infectious Diseases H7N9 infection Influenza Mortality Neuraminidase inhibitors Effectiveness |
| title | Effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory-confirmed avian influenza A H7N9 |
| title_full | Effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory-confirmed avian influenza A H7N9 |
| title_fullStr | Effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory-confirmed avian influenza A H7N9 |
| title_full_unstemmed | Effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory-confirmed avian influenza A H7N9 |
| title_short | Effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory-confirmed avian influenza A H7N9 |
| title_sort | effectiveness of neuraminidase inhibitors to prevent mortality in patients with laboratory confirmed avian influenza a h7n9 |
| topic | H7N9 infection Influenza Mortality Neuraminidase inhibitors Effectiveness |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220325510 |
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