Adipokines and cardiovascular disease: A comprehensive review
Adipokines are peptides that signal the functional status of adipose tissue to the brain and other target organs. In adipose tissue dysfunction, adipokine secretion is altered, and this can contribute to a spectrum of obesity-associated conditions including cardiovascular disease. Some adipokines ha...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Palacký University Olomouc, Faculty of Medicine and Dentistry
2017-03-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201701-0004_Adipokines_and_cardiovascular_disease_A_comprehensive_review.php |
| _version_ | 1819085249457422336 |
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| author | Ales Smekal Jan Vaclavik |
| author_facet | Ales Smekal Jan Vaclavik |
| author_sort | Ales Smekal |
| collection | DOAJ |
| description | Adipokines are peptides that signal the functional status of adipose tissue to the brain and other target organs. In adipose tissue dysfunction, adipokine secretion is altered, and this can contribute to a spectrum of obesity-associated conditions including cardiovascular disease. Some adipokines have anti-inflammatory and cardioprotective effects (omentin, apelin, adiponectin). Others are pro-inflammatory with negative impact on cardiovascular function (leptin, visfatin, resistin, adipocyte fatty-acid-binding protein). In the first part, this article reviews the endocrine functions of adipose tissue in general, effects of the distribution and composition of fat tissue, and the roles of cortisol and the renin-angiotensin-aldosterone system in the development of the inflammatory state of addipose tissue. In the second part, the known cardiovascular effects of different adipokines and their clinical potential are discussed in detail. |
| first_indexed | 2024-12-21T21:01:21Z |
| format | Article |
| id | doaj.art-f0399a89cd0a4860af8611d1c3973374 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-21T21:01:21Z |
| publishDate | 2017-03-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-f0399a89cd0a4860af8611d1c39733742022-12-21T18:50:27ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212017-03-011611314010.5507/bp.2017.002bio-201701-0004Adipokines and cardiovascular disease: A comprehensive reviewAles Smekal0Jan Vaclavik1Department of Internal Medicine I - Cardiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Internal Medicine I - Cardiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicAdipokines are peptides that signal the functional status of adipose tissue to the brain and other target organs. In adipose tissue dysfunction, adipokine secretion is altered, and this can contribute to a spectrum of obesity-associated conditions including cardiovascular disease. Some adipokines have anti-inflammatory and cardioprotective effects (omentin, apelin, adiponectin). Others are pro-inflammatory with negative impact on cardiovascular function (leptin, visfatin, resistin, adipocyte fatty-acid-binding protein). In the first part, this article reviews the endocrine functions of adipose tissue in general, effects of the distribution and composition of fat tissue, and the roles of cortisol and the renin-angiotensin-aldosterone system in the development of the inflammatory state of addipose tissue. In the second part, the known cardiovascular effects of different adipokines and their clinical potential are discussed in detail.https://biomed.papers.upol.cz/artkey/bio-201701-0004_Adipokines_and_cardiovascular_disease_A_comprehensive_review.phpadipokinesobesityadipose tissuecardiovascular effectsmyocardial infarctionheart failureomentinapelinadiponectinleptinvisfatinresistinadipocyte fatty-acid-binding protein |
| spellingShingle | Ales Smekal Jan Vaclavik Adipokines and cardiovascular disease: A comprehensive review Biomedical Papers adipokines obesity adipose tissue cardiovascular effects myocardial infarction heart failure omentin apelin adiponectin leptin visfatin resistin adipocyte fatty-acid-binding protein |
| title | Adipokines and cardiovascular disease: A comprehensive review |
| title_full | Adipokines and cardiovascular disease: A comprehensive review |
| title_fullStr | Adipokines and cardiovascular disease: A comprehensive review |
| title_full_unstemmed | Adipokines and cardiovascular disease: A comprehensive review |
| title_short | Adipokines and cardiovascular disease: A comprehensive review |
| title_sort | adipokines and cardiovascular disease a comprehensive review |
| topic | adipokines obesity adipose tissue cardiovascular effects myocardial infarction heart failure omentin apelin adiponectin leptin visfatin resistin adipocyte fatty-acid-binding protein |
| url | https://biomed.papers.upol.cz/artkey/bio-201701-0004_Adipokines_and_cardiovascular_disease_A_comprehensive_review.php |
| work_keys_str_mv | AT alessmekal adipokinesandcardiovasculardiseaseacomprehensivereview AT janvaclavik adipokinesandcardiovasculardiseaseacomprehensivereview |