Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia

Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia

Early T-cell development is precisely controlled by E proteins, that indistinguishably include HEB/TCF12 and E2A/TCF3 transcription factors, together with NOTCH1 and pre-T cell receptor (TCR) signalling. Importantly, perturbations of early T-cell regulatory networks are implicated in leukemogenesis....

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Bibliographic Details
Main Authors: Diogo F. T. Veiga, Mathieu Tremblay, Bastien Gerby, Sabine Herblot, André Haman, Patrick Gendron, Sébastien Lemieux, Juan Carlos Zúñiga-Pflücker, Josée Hébert, Joseph Paul Cohen, Trang Hoang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
SCL/TAL1
LMO1
HEB/TCF12
E2A/TCF3
NOTCH1
T-cell acute lymphoblastic leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.867443/full

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