G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway

G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway

Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) as the rate-limiting enzyme in the pentose phosphate pathway (PPP) is well-established as an aberrantly expressed protein in numerous clinical diseases; however, its role in cancer, specifically in multiple myeloma (MM) remains elusive. Me...

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Bibliographic Details
Main Authors: Rui Li, Mengying Ke, Mingming Qi, Zhenru Han, Yuhao Cao, Zhendong Deng, Jinjun Qian, Ye Yang, Chunyan Gu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Experimental Hematology & Oncology
Subjects:
Multiple myeloma
Glucose-6-phosphate dehydrogenase
Dehydroepiandrosterone
ROS
NADPH
Dexamethasone
Online Access:https://doi.org/10.1186/s40164-022-00326-6

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