Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain

Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain

Neuropathic pain is a common complication of diabetes with high morbidity and poor treatment outcomes. Accumulating evidence suggests the immune system is involved in the development of diabetic neuropathy, whilst neuro-immune interactions involving the kynurenine (KYN) and tetrahydrobiopterin (BH4)...

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Bibliographic Details
Main Authors: Ananda Staats Pires, Benjamin Heng, Vanessa X. Tan, Alexandra Latini, Marc A. Russo, Danielle M. Santarelli, Dominic Bailey, Katie Wynne, Jayden A. O’Brien, Gilles J. Guillemin, Paul J. Austin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
neuropathic pain
kynurenine
type 1 diabetes
tetrahydrobiopterin
pro-inflammatory cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00890/full

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