Nitric oxide-releasing gel accelerates healing in a diabetic murine splinted excisional wound model

Nitric oxide-releasing gel accelerates healing in a diabetic murine splinted excisional wound model

IntroductionAccording to the American Diabetes Association (ADA), 9–12 million patients suffer from chronic ulceration each year, costing the healthcare system over USD $25 billion annually. There is a significant unmet need for new and efficacious therapies to accelerate closure of non-healing woun...

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Main Authors: Dharshan Sivaraj, Chikage Noishiki, Nina Kosaric, Harriet Kiwanuka, Hudson C. Kussie, Dominic Henn, Katharina S. Fischer, Artem A. Trotsyuk, Autumn H. Greco, Britta A. Kuehlmann, Filiberto Quintero, Melissa C. Leeolou, Maia B. Granoski, Andrew C. Hostler, William W. Hahn, Michael Januszyk, Ferid Murad, Kellen Chen, Geoffrey C. Gurtner
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Medicine
Subjects:
nitric oxide
fibronectin
TGF-β1
wound healing
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1060758/full

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